HitPredict

Interactor 1: CFAD (P03953)
Complement factor D (EC 3.4.21.46) (28 kDa adipocyte protein) (Adipsin) (C3 convertase activator) (Properdin factor D)
Gene: Cfd

Interactor 2: LRP1 (Q91ZX7)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	30550785
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Trypsin~cEGF, EGF~Trypsin, FXa_inhibition~Trypsin, Ldl_recept_a~Trypsin
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 259 Mm			1 4545
+	Mm
		204901 CFAD_MOUSE (1-259): 2.94e-111: 322: 100.00		NOTC2_MOUSE (1-252): 2.26e-12: 76.4: 11.60
+	Mm
		398038 CFAD_MOUSE (1-259): 2.94e-111: 322: 100.00		NID1_MOUSE (3451-3704): 5.94e-09: 64.8: 16.06
+	Hs
		398002 KLKB1_HUMAN (3-256): 6.24e-103: 313: 30.30		NID2_HUMAN (3289-3648): 1.39e-09: 67.1: 22.96
+	Hs
		437661 HEPS_HUMAN (15-259): 1.79e-101: 303: 30.68		VLDLR_HUMAN (28-285): 5.68e-12: 74.5: 20.15
+	Hs
		437665 HEPS_HUMAN (15-259): 1.79e-101: 303: 30.68		NOTC2_HUMAN (2438-2817): 6.93e-11: 71.4: 11.78
+	Hs
		1047609 TM11B_HUMAN (13-253): 4.24e-101: 302: 31.73		NOTC2_HUMAN (2438-2817): 6.93e-11: 71.4: 11.78
+	Hs
		287523 KLK2_HUMAN (1-256): 2.92e-99: 292: 32.59		LRP6_HUMAN (3650-3808): 5.38e-10: 68.3: 19.16
+	Hs
		518735 GRAB_HUMAN (24-250): 8.96e-44: 150: 34.48		NOTC1_HUMAN (2840-3059): 1.46e-12: 77.2: 10.37
+	Hs
		287608 KLK15_HUMAN (16-256): 4.27e-45: 153: 37.40		LRP6_HUMAN (3650-3808): 5.38e-10: 68.3: 19.16
+	Hs
		274916 KLK15_HUMAN (16-256): 4.27e-45: 153: 37.40		LRP5_HUMAN (3660-3809): 2.26e-09: 66.4: 21.21
+	Hs
		376547 KLK15_HUMAN (16-256): 4.27e-45: 153: 37.40		LDLR_HUMAN (4018-4371): 2.73e-09: 65.6: 10.11
+	Hs
		287528 CMA1_HUMAN (18-256): 4.72e-39: 137: 33.74		LRP6_HUMAN (3650-3808): 5.38e-10: 68.3: 19.16
+	Hs
		376478 CMA1_HUMAN (18-256): 4.72e-39: 137: 33.74		LDLR_HUMAN (4018-4371): 2.73e-09: 65.6: 10.11
+	Hs
		663564 CMA1_HUMAN (18-256): 4.72e-39: 137: 33.74		SORL_HUMAN (2840-3042): 9.29e-09: 64.5: 20.00
+	Hs
		287512 KLK3_HUMAN (25-256): 3.05e-37: 133: 35.37		LRP6_HUMAN (3650-3808): 5.38e-10: 68.3: 19.16
+	Hs
		274851 KLK3_HUMAN (25-256): 3.05e-37: 133: 35.37		LRP5_HUMAN (3660-3809): 2.26e-09: 66.4: 21.21