HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: PTN4 (P29074)
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Gene: PTPN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 926
+	Hs
		412416 FYN_HUMAN (1-537): 0: 643: 100.00		E41L3_HUMAN (21-682): 1.53e-132: 427: 27.22
+	Hs
		523221 SRC_HUMAN (1-537): 0: 598: 68.21		E41L3_HUMAN (21-682): 1.53e-132: 427: 27.22
+	Hs
		522804 SRC_HUMAN (1-537): 0: 598: 68.21		PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46
+	Hs
		523042 SRC_HUMAN (1-537): 0: 598: 68.21		FRMD5_HUMAN (1-508): 4.92e-129: 402: 27.47
+	Hs
		412016 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRD_HUMAN (348-912): 2e-97: 338: 21.33
+	Hs
		411612 LCK_HUMAN (40-535): 0: 551: 57.60		PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46
+	Hs
		411596 LCK_HUMAN (40-535): 0: 551: 57.60		PTPRB_HUMAN (334-925): 1.77e-123: 415: 23.64
+	Hs
		411997 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45
+	Mm
		574000 FYN_MOUSE (1-537): 0: 642: 99.44		PTPRA_MOUSE (639-912): 1.11e-95: 321: 33.45
+	Rn
		1144045 FYN_RAT (1-537): 0: 641: 99.63		Q66HJ7_RAT (639-912): 1.14e-95: 321: 33.45
+	Rn
		1146020 SRC_RAT (1-537): 0: 601: 67.72		Q66HJ7_RAT (639-912): 1.14e-95: 321: 33.45
+	Mm
		403413 SRC_MOUSE (1-537): 0: 599: 68.33		PTPRA_MOUSE (639-912): 1.11e-95: 321: 33.45
+	Hs
		522756 SRC_HUMAN (1-537): 0: 598: 68.21		PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45
+	Rn
		976063 SRC_RAT (1-537): 0: 601: 67.72		PTPRA_RAT (639-912): 8.98e-93: 312: 33.45
+	Hs
		411696 LCK_HUMAN (40-535): 0: 551: 57.60		PTN13_HUMAN (618-912): 9.57e-104: 357: 35.02
+	Rn
		94284 FYN_RAT (1-537): 0: 641: 99.63		F1LXJ9_RAT (649-914): 3.89e-55: 210: 28.21
+	Hs
		412018 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRZ_HUMAN (565-912): 7.52e-53: 203: 20.44
+	Hs
		411609 LCK_HUMAN (40-535): 0: 551: 57.60		PTPRM_HUMAN (522-915): 3.45e-59: 223: 22.36
+	Hs
		411598 LCK_HUMAN (40-535): 0: 551: 57.60		PTPRZ_HUMAN (565-912): 7.52e-53: 203: 20.44
+	Hs
		411597 LCK_HUMAN (40-535): 0: 551: 57.60		PTPRG_HUMAN (671-917): 8.47e-50: 193: 23.74