HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030425 - dendrite GO:0032930 - positive regulation of superoxide anion generation and 1 others more... GO:0044297 - cell body
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 758
+	Hs
		529571 GNAI1_HUMAN (1-355): 7.82e-178: 499: 87.89		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		475879 GNAI3_HUMAN (1-355): 8.25e-175: 491: 85.92		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		482573 GNAO_HUMAN (1-355): 1.32e-173: 488: 69.30		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529353 GNAQ_HUMAN (1-354): 9.29e-165: 465: 50.42		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529158 GNA11_HUMAN (1-354): 4.9e-162: 459: 50.42		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529044 GNAZ_HUMAN (1-354): 7.1e-160: 453: 66.38		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Mm
		475857 GNAI2_MOUSE (1-355): 2.04e-178: 500: 98.31		TAU_MOUSE (1-758): 8.57e-72: 250: 70.17
+	Hs
		349311 GNA14_HUMAN (3-354): 2.11e-158: 449: 49.86		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Mm
		73958 GNAI1_MOUSE (1-355): 7.82e-178: 499: 87.89		TAU_MOUSE (1-758): 8.57e-72: 250: 70.17
+	Rn
		620025 GNAO_RAT (1-355): 9.09e-172: 483: 68.45		TAU_RAT (1-758): 3.21e-76: 263: 72.11
+	Rn
		98716 GNAO_RAT (1-355): 9.09e-172: 483: 68.45		F1LST4_RAT (1-757): 7.75e-76: 262: 72.21
+	Hs
		529796 GNA13_HUMAN (2-354): 6.74e-153: 436: 39.72		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529570 GNAS2_HUMAN (1-355): 7.36e-145: 417: 38.83		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Mm
		530706 GNAQ_MOUSE (1-354): 5.38e-165: 466: 50.42		TAU_MOUSE (1-758): 8.57e-72: 250: 70.17
+	Mm
		530705 GNA11_MOUSE (1-354): 8.06e-163: 460: 50.99		TAU_MOUSE (1-758): 8.57e-72: 250: 70.17
+	Mm
		267010 GNAZ_MOUSE (1-354): 1.68e-160: 455: 65.82		TAU_MOUSE (1-758): 8.57e-72: 250: 70.17