Interactor 1: HEXA (P06865)
Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)
Gene: HEXA

Interactor 2: HEXB (P07686)
Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
Gene: HEXB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.866

The method score is based on:

Property Details
Experiments 28514442, 33961781, 16698036
Identification Methods affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Glyco_hydro_20~Glyco_hydro_20, Glyco_hydro_20~Glycohydro_20b2, Glycohydro_20b2~Glycohydro_20b2
Common GO terms GO:0001501 - skeletal system development
GO:0004563 - beta-N-acetylhexosaminidase activity
GO:0005764 - lysosome
GO:0006689 - ganglioside catabolic process
GO:0007040 - lysosome organization
and 15 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 529
Hs

1 556
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024