Protein: GPR35
G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor)

Gene: GPR35
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q9HC97

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007010 - cytoskeleton organization
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007204 - positive regulation of cytosolic calcium ion concentration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1329977

GP161
G-protein coupled receptor 161

1

18

High-throughput

0.698

High

1385960

GP146
G-protein coupled receptor 146

1

16

High-throughput

0.698

High

1125932

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

20

High-throughput

0.691

High

609811

LEG3
Galectin-3

3

6

High-throughput

0.667

High

329014

RTN3
Reticulon-3

2

9

High-throughput

0.633

High

1154079

MSMO1
Methylsterol monooxygenase 1

2

6

High-throughput

0.633

High

443983

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

11

High-throughput

0.628

High

482637

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

20

High-throughput

0.618

High

648030

CCL1
C-C motif chemokine 1

1

20

Small-scale

0.618

High

1247523

POTEE
POTE ankyrin domain family member E

3

11

High-throughput

0.609

High

226455

SNG2
Synaptogyrin-2

2

3

High-throughput

0.578

High

1203397

YIF1B
Protein YIF1B

2

4

High-throughput

0.578

High

1438767

T161A
Transmembrane protein 161A

2

6

High-throughput

0.578

High

1438778

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

2

6

High-throughput

0.578

High

1438772

ATIF1
ATPase inhibitor, mitochondrial

2

3

High-throughput

0.574

High

155253

AGRB1
Adhesion G protein-coupled receptor B1

1

14

High-throughput

0.541

High

178402

NPC1
NPC intracellular cholesterol transporter 1

1

5

High-throughput

0.541

High

190565

COPT2
Protein SLC31A2

1

1

High-throughput

0.541

High

420705

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

20

High-throughput

0.541

High

538693

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.541

High

835584

TSN7
Tetraspanin-7

1

18

High-throughput

0.541

High

870035

KCNJ4
Inward rectifier potassium channel 4

1

3

High-throughput

0.541

High

948937

CD81
CD81 antigen

1

16

High-throughput

0.541

High

1023396

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.541

High

1102479

CRFR2
Corticotropin-releasing factor receptor 2

1

11

High-throughput

0.541

High

1322314

SPART
Spartin

1

2

High-throughput

0.541

High

1403632

SL9A7
Sodium/hydrogen exchanger 7

1

3

High-throughput

0.541

High

1428891

MCLN1
Mucolipin-1

1

2

High-throughput

0.541

High

1438762

RTN4
Reticulon-4

1

9

High-throughput

0.541

High

1438770

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

1

High-throughput

0.541

High

1438776

PLLP
Plasmolipin

1

6

High-throughput

0.541

High

133586

ACATN
Acetyl-coenzyme A transporter 1

1

3

High-throughput

0.536

High

163359

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

4

High-throughput

0.536

High

170539

RAB7L
Ras-related protein Rab-7L1

1

8

High-throughput

0.536

High

184517

SURF4
Surfeit locus protein 4

1

2

High-throughput

0.536

High

256160

S19A2
Thiamine transporter 1

1

8

High-throughput

0.536

High

270689

ATP9A
Probable phospholipid-transporting ATPase IIA

1

11

High-throughput

0.536

High

565714

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

20

High-throughput

0.536

High

641031

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

8

High-throughput

0.536

High

680513

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

11

High-throughput

0.536

High

878097

AGRE5
Adhesion G protein-coupled receptor E5

1

12

High-throughput

0.536

High

933482

S12A2
Solute carrier family 12 member 2

1

7

High-throughput

0.536

High

934286

BI1
Bax inhibitor 1

1

5

High-throughput

0.536

High

1105246

S39A6
Zinc transporter ZIP6

1

18

High-throughput

0.536

High

1329525

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

2

High-throughput

0.536

High

1408201

RNF5
E3 ubiquitin-protein ligase RNF5

1

10

High-throughput

0.536

High

1421254

TTYH3
Protein tweety homolog 3

1

5

High-throughput

0.536

High

1428162

YIPF3
Protein YIPF3

1

6

High-throughput

0.536

High

1433182

PIGU
GPI-anchor transamidase component PIGU

1

3

High-throughput

0.536

High

1438761

GPC5C
G-protein coupled receptor family C group 5 member C

1

4

High-throughput

0.536

High

1438768

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

5

High-throughput

0.536

High

1307707

PLDX1
Plexin domain-containing protein 1

1

0

High-throughput

0.518

High

1329198

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.518

High

1356111

SCRB1
Scavenger receptor class B member 1

1

0

High-throughput

0.518

High

1384646

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.518

High

1413251

SYT11
Synaptotagmin-11

1

0

High-throughput

0.518

High

1438766

AIG1
Androgen-induced gene 1 protein

1

0

High-throughput

0.518

High

1438774

NAC2
Sodium/calcium exchanger 2

1

0

High-throughput

0.518

High

1438779

SELK
Selenoprotein K

1

0

High-throughput

0.518

High

229246

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

5

High-throughput

0.494

High

316570

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

2

High-throughput

0.494

High

352808

CH25H
Cholesterol 25-hydroxylase

1

6

High-throughput

0.494

High

391663

FRIH
Ferritin heavy chain

1

1

High-throughput

0.494

High

665013

ERD21
ER lumen protein-retaining receptor 1

1

5

High-throughput

0.494

High

699149

CALX
Calnexin

1

6

High-throughput

0.494

High

943551

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

3

High-throughput

0.494

High

1091985

SEC20
Vesicle transport protein SEC20

1

1

High-throughput

0.494

High

1152868

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.494

High

1212558

CXG2
Gap junction gamma-2 protein

1

9

High-throughput

0.494

High

1254205

PPR3F
Protein phosphatase 1 regulatory subunit 3F

1

1

High-throughput

0.494

High

1308216

PLD3
5'-3' exonuclease PLD3

1

3

High-throughput

0.494

High

1398565

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

1

9

High-throughput

0.494

High

1432668

GHITM
Growth hormone-inducible transmembrane protein

1

5

High-throughput

0.494

High

1438769

ZDHC3
Palmitoyltransferase ZDHHC3

1

2

High-throughput

0.494

High

1438775

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

5

High-throughput

0.494

High

161256

EI24
Etoposide-induced protein 2.4 homolog

1

1

High-throughput

0.489

High

165660

SCAM3
Secretory carrier-associated membrane protein 3

1

8

High-throughput

0.489

High

178988

SCAM2
Secretory carrier-associated membrane protein 2

1

8

High-throughput

0.489

High

298811

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

3

High-throughput

0.489

High

299697

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

2

High-throughput

0.489

High

344495

STR3N
STARD3 N-terminal-like protein

1

1

High-throughput

0.489

High

397709

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

3

High-throughput

0.489

High

431410

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

1

High-throughput

0.489

High

665724

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

5

High-throughput

0.489

High

784732

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

4

High-throughput

0.489

High

963600

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

3

High-throughput

0.489

High

1043181

TAP1
Antigen peptide transporter 1

1

9

High-throughput

0.489

High

1053842

KDSR
3-ketodihydrosphingosine reductase

1

6

High-throughput

0.489

High

1141555

OXA1L
Mitochondrial inner membrane protein OXA1L

1

3

High-throughput

0.489

High

1198404

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

7

High-throughput

0.489

High

1204595

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

11

High-throughput

0.489

High

1251754

CERS6
Ceramide synthase 6

1

17

High-throughput

0.489

High

1288666

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

7

High-throughput

0.489

High

1307558

ZDH13
Palmitoyltransferase ZDHHC13

1

9

High-throughput

0.489

High

1307646

ZDH17
Palmitoyltransferase ZDHHC17

1

10

High-throughput

0.489

High

1315486

K2013
Uncharacterized protein KIAA2013

1

6

High-throughput

0.489

High

1337962

ZNT7
Zinc transporter 7

1

11

High-throughput

0.489

High

1348329

GOGA5
Golgin subfamily A member 5

1

6

High-throughput

0.489

High

1361366

BRI3B
BRI3-binding protein

1

2

High-throughput

0.489

High

1372397

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

1380489

YIPF5
Protein YIPF5

1

6

High-throughput

0.489

High

1382726

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.489

High

1384186

TM186
Transmembrane protein 186

1

2

High-throughput

0.489

High

1386932

F241B
Protein FAM241B

1

2

High-throughput

0.489

High

1388804

YIPF6
Protein YIPF6

1

6

High-throughput

0.489

High

1389667

MFSD3
Major facilitator superfamily domain-containing protein 3

1

5

High-throughput

0.489

High

1391301

CERS2
Ceramide synthase 2

1

17

High-throughput

0.489

High

1392174

RUSF1
RUS family member 1

1

5

High-throughput

0.489

High

1401708

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

5

High-throughput

0.489

High

1415276

PTSS2
Phosphatidylserine synthase 2

1

8

High-throughput

0.489

High

1428307

DERL2
Derlin-2

1

5

High-throughput

0.489

High

1435756

AT133
Polyamine-transporting ATPase 13A3

1

20

High-throughput

0.489

High

1438764

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

4

High-throughput

0.489

High

1438765

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

12

High-throughput

0.489

High

1438773

TMCO1
Calcium load-activated calcium channel

1

4

High-throughput

0.489

High

1438777

TNPO3
Transportin-3

1

20

High-throughput

0.489

High

409508

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.481

High

463229

YES
Tyrosine-protein kinase Yes

1

6

High-throughput

0.479

High

1210664

Q5SUL5
HLA class I histocompatibility antigen A alpha chain

1

4

High-throughput

0.417

High

1389155

KTI12
Protein KTI12 homolog

3

0

High-throughput

0.347

High

155404

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

0

High-throughput

0.282

High

261560

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.282

High

873417

LSS
Lanosterol synthase

1

0

High-throughput

0.282

High

1085160

TMM94
Transmembrane protein 94

1

0

High-throughput

0.282

High

1203521

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.282

High

1349667

ZFAN1
AN1-type zinc finger protein 1

1

0

High-throughput

0.282

High

1411119

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

High-throughput

0.282

High

1414296

ABHEA
Protein ABHD14A

1

0

High-throughput

0.282

High

1438763

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

0

High-throughput

0.282

High

1438771

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.282

High

1083208

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1421143

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025