HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	22939624, 29777862, 31980649, 32707033, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 606
+	Hs
		432156 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q96II5_HUMAN (1-606): 0: 573: 99.51
+	Hs
		437832 HS90B_HUMAN (19-732): 0: 1059: 86.13		ARAF_HUMAN (1-606): 0: 579: 100.00
+	Hs
		431496 HS90A_HUMAN (1-732): 0: 1087: 100.00		BRAF_HUMAN (3-604): 0: 546: 56.68
+	Mm
		432406 HS90A_MOUSE (1-732): 0: 1083: 97.82		BRAF_MOUSE (3-604): 0: 542: 55.81
+	Hs
		373543 HS90A_HUMAN (1-732): 0: 1087: 100.00		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Hs
		437860 HS90B_HUMAN (19-732): 0: 1059: 86.13		BRAF_HUMAN (3-604): 0: 546: 56.68
+	Gg
		513713 HS90A_CHICK (1-732): 0: 1061: 95.22		BRAF_CHICK (3-604): 0: 542: 56.20
+	Hs
		373549 HS90B_HUMAN (19-732): 0: 1059: 86.13		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Rn
		88624 HS90A_RAT (1-732): 0: 1085: 97.95		D3ZHL1_RAT (50-606): 1.21e-128: 401: 25.66
+	Hs
		432033 HS90A_HUMAN (1-732): 0: 1087: 100.00		KSR1_HUMAN (50-606): 7.14e-122: 384: 24.24
+	Hs
		431433 HS90A_HUMAN (1-732): 0: 1087: 100.00		YES_HUMAN (289-568): 3.31e-104: 327: 31.34
+	Hs
		431481 HS90A_HUMAN (1-732): 0: 1087: 100.00		SRC_HUMAN (282-568): 1.92e-104: 327: 30.24
+	Hs
		433218 HS90B_HUMAN (19-732): 0: 1059: 86.13		YES_HUMAN (289-568): 3.31e-104: 327: 31.34
+	Hs
		437847 HS90B_HUMAN (19-732): 0: 1059: 86.13		SRC_HUMAN (282-568): 1.92e-104: 327: 30.24
+	Hs
		431975 HS90A_HUMAN (1-732): 0: 1087: 100.00		KSR2_HUMAN (303-584): 2.02e-45: 174: 36.30
+	Hs
		411945 HS90A_HUMAN (1-732): 0: 1087: 100.00		FYN_HUMAN (303-568): 1.51e-37: 148: 33.46
+	Hs
		438285 HS90B_HUMAN (19-732): 0: 1059: 86.13		KSR2_HUMAN (303-584): 2.02e-45: 174: 36.30
+	Hs
		431627 HS90A_HUMAN (1-732): 0: 1087: 100.00		FRK_HUMAN (303-568): 1.34e-36: 145: 33.70
+	Hs
		411949 HS90B_HUMAN (19-732): 0: 1059: 86.13		FYN_HUMAN (303-568): 1.51e-37: 148: 33.46
+	Hs
		437967 HS90B_HUMAN (19-732): 0: 1059: 86.13		FRK_HUMAN (303-568): 1.34e-36: 145: 33.70