HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: KAPCG (P22612)
cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)
Gene: PRKACG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 351
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (1-351): 1.79e-162: 459: 82.91
+	Hs
		437900 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCB_HUMAN (1-351): 1.01e-160: 455: 78.63
+	Hs
		431537 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCG_HUMAN (1-351): 6.75e-163: 460: 100.00
+	Hs
		431511 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCA_HUMAN (1-351): 1.79e-162: 459: 82.91
+	Hs
		70435 HS90A_HUMAN (1-724): 0: 1072: 85.25		B2RB89_HUMAN (1-351): 1.01e-160: 455: 78.63
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (2-347): 5.57e-150: 432: 35.51
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (2-347): 1.94e-147: 426: 38.46
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (7-347): 3.74e-148: 428: 38.26
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (2-347): 4.97e-148: 427: 38.46
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (1-351): 2.27e-144: 425: 35.79
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (7-347): 4.44e-147: 425: 38.51
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (4-351): 2.87e-139: 414: 34.07
+	Hs
		438013 HS90B_HUMAN (1-724): 0: 1086: 100.00		PRKX_HUMAN (8-351): 2.34e-143: 411: 43.35
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (30-351): 2.57e-140: 408: 36.72
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (24-351): 1.4e-139: 407: 35.48
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (7-340): 3.02e-138: 401: 39.53
+	Hs
		438541 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK2_HUMAN (1-340): 2.1e-139: 401: 40.58
+	Hs
		116956 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGK1_HUMAN (7-340): 3.02e-138: 401: 39.53
+	Hs
		438131 HS90B_HUMAN (1-724): 0: 1086: 100.00		KGP2_HUMAN (39-335): 6.67e-85: 273: 44.41
+	Hs
		217856 HS90B_HUMAN (1-724): 0: 1086: 100.00		PRKY_HUMAN (45-267): 6.93e-87: 265: 50.22