HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: E41L3 (Q9Y2J2)
Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]
Gene: EPB41L3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 1087
+	Hs
		440796 FYN_HUMAN (1-507): 0: 587: 54.19		E41L3_HUMAN (1-1087): 0: 755: 100.00
+	Hs
		557542 SRC_HUMAN (20-507): 0: 585: 55.00		E41L3_HUMAN (1-1087): 0: 755: 100.00
+	Hs
		463855 LYN_HUMAN (1-509): 0: 581: 62.72		E41L3_HUMAN (1-1087): 0: 755: 100.00
+	Hs
		440221 LCK_HUMAN (1-509): 0: 655: 100.00		E41L5_HUMAN (74-736): 8.29e-137: 432: 26.70
+	Hs
		440088 LCK_HUMAN (1-509): 0: 655: 100.00		PTN14_HUMAN (91-1064): 2.04e-118: 395: 14.97
+	Hs
		440050 LCK_HUMAN (1-509): 0: 655: 100.00		PTN13_HUMAN (4-990): 1.31e-113: 391: 16.50
+	Hs
		440258 LCK_HUMAN (1-509): 0: 655: 100.00		FARP1_HUMAN (73-662): 2.31e-114: 381: 28.81
+	Hs
		440390 FYN_HUMAN (1-507): 0: 587: 54.19		PTN4_HUMAN (91-725): 5.54e-140: 446: 28.81
+	Hs
		463780 LYN_HUMAN (1-509): 0: 581: 62.72		E41L5_HUMAN (74-736): 8.29e-137: 432: 26.70
+	Hs
		463764 LYN_HUMAN (1-509): 0: 581: 62.72		E41LB_HUMAN (106-908): 7.11e-129: 416: 20.80
+	Hs
		557362 SRC_HUMAN (20-507): 0: 585: 55.00		FRMD5_HUMAN (108-582): 2e-124: 394: 29.73
+	Hs
		557330 SRC_HUMAN (20-507): 0: 585: 55.00		PTN21_HUMAN (91-1043): 6.52e-118: 393: 18.41
+	Hs
		463535 LYN_HUMAN (1-509): 0: 581: 62.72		PTN14_HUMAN (91-1064): 2.04e-118: 395: 14.97
+	Hs
		463486 LYN_HUMAN (1-509): 0: 581: 62.72		PTN13_HUMAN (4-990): 1.31e-113: 391: 16.50
+	Hs
		320526 LYN_HUMAN (1-509): 0: 581: 62.72		FARP2_HUMAN (79-583): 3.8e-117: 389: 30.10
+	Hs
		463375 LYN_HUMAN (1-509): 0: 581: 62.72		RADI_HUMAN (106-654): 9.34e-114: 366: 19.65
+	Hs
		440209 LCK_HUMAN (1-509): 0: 655: 100.00		E41L1_HUMAN (623-1084): 1.24e-22: 106: 21.00
+	Hs
		217371 LYN_HUMAN (1-509): 0: 581: 62.72		E41L2_HUMAN (583-1087): 5.65e-45: 178: 32.45
+	Hs
		463297 LYN_HUMAN (1-509): 0: 581: 62.72		EPB41_HUMAN (701-1083): 1.39e-42: 170: 32.82
+	Hs
		463768 LYN_HUMAN (1-509): 0: 581: 62.72		E41L1_HUMAN (623-1084): 1.24e-22: 106: 21.00