HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: PTN4 (P29074)
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Gene: PTPN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 926
+	Hs
		440796 FYN_HUMAN (1-537): 0: 644: 100.00		E41L3_HUMAN (21-682): 2.06e-131: 423: 27.22
+	Hs
		557542 SRC_HUMAN (1-537): 0: 598: 68.21		E41L3_HUMAN (21-682): 2.06e-131: 423: 27.22
+	Hs
		557122 SRC_HUMAN (1-537): 0: 598: 68.21		PTN6_HUMAN (546-913): 7.17e-135: 418: 32.46
+	Mm
		59107 FYN_MOUSE (1-537): 0: 643: 99.44		PTPRF_MOUSE (303-912): 1.85e-104: 359: 20.21
+	Hs
		557362 SRC_HUMAN (1-537): 0: 598: 68.21		FRMD5_HUMAN (1-508): 1.78e-129: 403: 27.47
+	Hs
		440371 FYN_HUMAN (1-537): 0: 644: 100.00		PTPRD_HUMAN (348-912): 3.11e-99: 344: 21.33
+	Hs
		440539 FYN_HUMAN (1-537): 0: 644: 100.00		PTPRS_HUMAN (317-912): 1.78e-99: 344: 20.03
+	Hs
		439950 LCK_HUMAN (40-535): 0: 552: 57.40		PTPRB_HUMAN (334-925): 1.24e-124: 418: 23.64
+	Hs
		440351 FYN_HUMAN (1-537): 0: 644: 100.00		PTPRA_HUMAN (639-912): 1.1e-96: 323: 33.45
+	Rn
		1224293 FYN_RAT (1-537): 0: 643: 99.63		Q66HJ7_RAT (639-912): 1.61e-96: 323: 33.45
+	Mm
		611446 FYN_MOUSE (1-537): 0: 643: 99.44		PTPRA_MOUSE (640-912): 5.58e-96: 322: 33.57
+	Rn
		1226359 SRC_RAT (1-537): 0: 601: 67.72		Q66HJ7_RAT (639-912): 1.61e-96: 323: 33.45
+	Mm
		431321 SRC_MOUSE (1-537): 0: 600: 68.52		PTPRA_MOUSE (640-912): 5.58e-96: 322: 33.57
+	Hs
		557073 SRC_HUMAN (1-537): 0: 598: 68.21		PTPRA_HUMAN (639-912): 1.1e-96: 323: 33.45
+	Rn
		1042469 SRC_RAT (1-537): 0: 601: 67.72		PTPRA_RAT (639-912): 2.3e-93: 314: 33.45
+	Rn
		98818 FYN_RAT (1-537): 0: 643: 99.63		F1LXJ9_RAT (649-914): 8.99e-56: 212: 28.57
+	Hs
		440373 FYN_HUMAN (1-537): 0: 644: 100.00		PTPRZ_HUMAN (565-912): 3.73e-53: 205: 20.44
+	Hs
		439963 LCK_HUMAN (40-535): 0: 552: 57.40		PTPRM_HUMAN (522-915): 2.1e-59: 223: 21.87
+	Hs
		439952 LCK_HUMAN (40-535): 0: 552: 57.40		PTPRZ_HUMAN (565-912): 3.73e-53: 205: 20.44
+	Hs
		439951 LCK_HUMAN (40-535): 0: 552: 57.40		PTPRG_HUMAN (665-917): 1.75e-50: 195: 23.68