HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: SOS2 (Q07890)
Son of sevenless homolog 2 (SOS-2)
Gene: SOS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 1332
+	Hs
		557253 SRC_HUMAN (1-537): 0: 598: 68.21		SOS2_HUMAN (1-1332): 0: 947: 100.00
+	Hs
		440511 FYN_HUMAN (1-537): 0: 644: 100.00		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		557252 SRC_HUMAN (1-537): 0: 598: 68.21		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		362263 ABL1_HUMAN (21-537): 2.78e-166: 502: 38.15		SOS2_HUMAN (1-1332): 0: 947: 100.00
+	Hs
		440044 LCK_HUMAN (40-535): 0: 552: 57.40		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		473405 HCK_HUMAN (1-535): 0: 549: 56.64		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		362262 ABL1_HUMAN (21-537): 2.78e-166: 502: 38.15		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Dm
		688363 SRC42_DROME (35-535): 0: 539: 55.25		SOS_DROME (8-1329): 0: 697: 42.50
+	Hs
		440548 FYN_HUMAN (1-537): 0: 644: 100.00		RPGF1_HUMAN (571-1020): 8.81e-96: 334: 25.99
+	Hs
		440335 FYN_HUMAN (1-537): 0: 644: 100.00		VAV_HUMAN (54-665): 1.37e-86: 303: 13.04
+	Hs
		557292 SRC_HUMAN (1-537): 0: 598: 68.21		RPGF1_HUMAN (571-1020): 8.81e-96: 334: 25.99
+	Hs
		557294 SRC_HUMAN (1-537): 0: 598: 68.21		RGRF1_HUMAN (10-649): 4.02e-91: 324: 13.43
+	Hs
		238796 FYN_HUMAN (1-537): 0: 644: 100.00		KALRN_HUMAN (8-626): 8.99e-65: 245: 11.41
+	Hs
		473415 HCK_HUMAN (1-535): 0: 549: 56.64		RPGF1_HUMAN (571-1020): 8.81e-96: 334: 25.99
+	Hs
		439933 LCK_HUMAN (40-535): 0: 552: 57.40		VAV_HUMAN (54-665): 1.37e-86: 303: 13.04
+	Hs
		362287 ABL1_HUMAN (21-537): 2.78e-166: 502: 38.15		RPGF1_HUMAN (571-1020): 8.81e-96: 334: 25.99
+	Hs
		362147 ABL1_HUMAN (21-537): 2.78e-166: 502: 38.15		VAV_HUMAN (54-665): 1.37e-86: 303: 13.04
+	Mm
		362450 ABL1_MOUSE (21-537): 1.52e-166: 503: 38.65		Q8C5V7_MOUSE (549-1018): 1.03e-86: 298: 25.11
+	Hs
		238795 LCK_HUMAN (40-535): 0: 552: 57.40		KALRN_HUMAN (8-626): 8.99e-65: 245: 11.41
+	Hs
		584487 TEC_HUMAN (5-529): 2.08e-163: 480: 34.89		VAV_HUMAN (54-665): 1.37e-86: 303: 13.04