HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	9856337, 17474147
Identification Methods	pull down, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0014069 - postsynaptic density GO:0050900 - leukocyte migration and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 1333
+	Hs
		557252 SRC_HUMAN (1-537): 0: 598: 68.21		SOS1_HUMAN (1-1333): 0: 1000: 100.00
+	Hs
		440044 LCK_HUMAN (40-535): 0: 552: 57.40		SOS1_HUMAN (1-1333): 0: 1000: 100.00
+	Hs
		473405 HCK_HUMAN (1-535): 0: 549: 56.64		SOS1_HUMAN (1-1333): 0: 1000: 100.00
+	Hs
		362262 ABL1_HUMAN (21-537): 2.78e-166: 502: 38.15		SOS1_HUMAN (1-1333): 0: 1000: 100.00
+	Hs
		440512 FYN_HUMAN (1-537): 0: 644: 100.00		SOS2_HUMAN (1-1131): 0: 858: 73.59
+	Hs
		557253 SRC_HUMAN (1-537): 0: 598: 68.21		SOS2_HUMAN (1-1131): 0: 858: 73.59
+	Hs
		362263 ABL1_HUMAN (21-537): 2.78e-166: 502: 38.15		SOS2_HUMAN (1-1131): 0: 858: 73.59
+	Dm
		688363 SRC42_DROME (35-535): 0: 539: 55.25		SOS_DROME (8-1333): 0: 704: 41.74
+	Hs
		440548 FYN_HUMAN (1-537): 0: 644: 100.00		RPGF1_HUMAN (571-1032): 2.17e-92: 324: 23.63
+	Hs
		557294 SRC_HUMAN (1-537): 0: 598: 68.21		RGRF1_HUMAN (10-785): 3.35e-99: 347: 12.97
+	Hs
		440335 FYN_HUMAN (1-537): 0: 644: 100.00		VAV_HUMAN (133-667): 1.01e-80: 286: 14.15
+	Hs
		557292 SRC_HUMAN (1-537): 0: 598: 68.21		RPGF1_HUMAN (571-1032): 2.17e-92: 324: 23.63
+	Hs
		238796 FYN_HUMAN (1-537): 0: 644: 100.00		KALRN_HUMAN (8-624): 5.23e-69: 259: 12.70
+	Hs
		473415 HCK_HUMAN (1-535): 0: 549: 56.64		RPGF1_HUMAN (571-1032): 2.17e-92: 324: 23.63
+	Hs
		439933 LCK_HUMAN (40-535): 0: 552: 57.40		VAV_HUMAN (133-667): 1.01e-80: 286: 14.15
+	Hs
		238795 LCK_HUMAN (40-535): 0: 552: 57.40		KALRN_HUMAN (8-624): 5.23e-69: 259: 12.70
+	Hs
		362147 ABL1_HUMAN (21-537): 2.78e-166: 502: 38.15		VAV_HUMAN (133-667): 1.01e-80: 286: 14.15
+	Hs
		299505 LCK_HUMAN (40-535): 0: 552: 57.40		TRIO_HUMAN (121-694): 3.12e-61: 234: 12.54
+	Mm
		362450 ABL1_MOUSE (21-537): 1.52e-166: 503: 38.65		Q8C5V7_MOUSE (549-1004): 2.71e-80: 279: 22.71
+	Hs
		299507 LYN_HUMAN (1-535): 0: 537: 54.48		TRIO_HUMAN (121-694): 3.12e-61: 234: 12.54