Protein: SOS2
Son of sevenless homolog 2 (SOS-2)

Gene: SOS2
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q07890

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007265 - Ras protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987578

GRB2
Growth factor receptor-bound protein 2

17

20

Small-scale

0.986

High

855599

CRK
Adapter molecule crk

3

20

High-throughput

0.861

High

619038

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

8

Small-scale

0.852

High

593975

NCK1
SH2/SH3 adapter protein NCK1

3

20

High-throughput

0.839

High

363176

EGFR
Epidermal growth factor receptor

9

20

Small-scale

0.748

High

249125

DSCAM
Cell adhesion molecule DSCAM

1

4

High-throughput

0.698

High

1060709

ITSN1
Intersectin-1

1

18

High-throughput

0.698

High

855856

CRKL
Crk-like protein

1

20

High-throughput

0.691

High

1060729

SNX9
Sorting nexin-9

1

3

Small-scale

0.665

High

292826

GRAP2
GRB2-related adapter protein 2

1

20

Small-scale

0.647

High

1060722

ITSN2
Intersectin-2

1

12

High-throughput

0.621

High

362263

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

440512

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.618

High

557253

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.618

High

1060728

CD2AP
CD2-associated protein

1

20

Small-scale

0.618

High

711326

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.584

High

222065

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.575

High

134697

SAP18
Histone deacetylase complex subunit SAP18

2

1

High-throughput

0.571

High

790890

TAGL2
Transgelin-2

2

1

High-throughput

0.571

High

1060719

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

2

1

High-throughput

0.571

High

553178

KCRB
Creatine kinase B-type

2

0

High-throughput

0.547

High

647544

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

0

High-throughput

0.547

High

1048303

LGUL
Lactoylglutathione lyase

2

0

High-throughput

0.547

High

943758

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

17

High-throughput

0.541

High

1060708

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.536

High

717451

PDIA3
Protein disulfide-isomerase A3

2

4

High-throughput

0.521

High

932854

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

2

High-throughput

0.521

High

962936

CH10
10 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.521

High

1060717

FUBP3
Far upstream element-binding protein 3

2

5

High-throughput

0.521

High

1060724

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

9

Small-scale

0.515

High

138484

BIN1
Myc box-dependent-interacting protein 1

1

8

Small-scale

0.501

High

1060715

CBP
CREB-binding protein

1

2

Small-scale

0.481

High

395982

ESR1
Estrogen receptor

1

11

Small-scale

0.479

High

411802

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

413699

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

699713

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

High-throughput

0.479

High

704519

RXRB
Retinoic acid receptor RXR-beta

1

7

High-throughput

0.479

High

910863

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.479

High

941144

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

949139

TPIS
Triosephosphate isomerase

1

1

High-throughput

0.479

High

1060711

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

2

High-throughput

0.479

High

1060718

SNX18
Sorting nexin-18

1

3

Small-scale

0.479

High

1060720

NEB2
Neurabin-2

1

13

High-throughput

0.479

High

1060725

TPX2
Targeting protein for Xklp2

1

3

High-throughput

0.479

High

533651

CLUS
Clusterin

1

1

High-throughput

0.457

High

895542

SERPH
Serpin H1

1

5

High-throughput

0.437

High

1060710

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1060713

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

1

High-throughput

0.437

High

1060726

SF3B6
Splicing factor 3B subunit 6

1

2

High-throughput

0.437

High

751317

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

2

0

High-throughput

0.298

High

1060716

EVI5L
EVI5-like protein

2

0

High-throughput

0.298

High

1060727

NOP16
Nucleolar protein 16

2

0

High-throughput

0.298

High

756162

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.249

Low

1060712

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.249

Low

1060714

PABP2
Polyadenylate-binding protein 2

1

0

High-throughput

0.249

Low

1060721

RBM15
RNA-binding protein 15

1

0

High-throughput

0.249

Low

1060723

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.249

Low

702183

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025