HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.27 1.00 0.527

The method score is based on:

Property Details
Experiments 16274251
Identification Methods unspecified method
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0019901 - protein kinase binding
GO:0042110 - T cell activation
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 11Aug2025