HitPredict

Interactor 1: LEG1 (P09382)
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
Gene: LGALS1

Interactor 2: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Gal-bind_lectin~V-set
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 135 Hs			1 646
+	Hs
		572314 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		121126 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		449258 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		CD166_HUMAN (13-607): 2.71e-98: 314: 22.33
+	Hs
		572356 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		CD166_HUMAN (13-607): 2.71e-98: 314: 22.33
+	Hs
		121151 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		CD166_HUMAN (13-607): 2.71e-98: 314: 22.33
+	Hs
		119364 LEG9_HUMAN (10-133): 2.96e-35: 126: 31.50		CD166_HUMAN (13-607): 2.71e-98: 314: 22.33
+	Hs
		1045045 LEG9B_HUMAN (10-133): 1.12e-34: 124: 30.71		CD166_HUMAN (13-607): 2.71e-98: 314: 22.33
+	Hs
		449252 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		PTK7_HUMAN (17-627): 1.64e-70: 249: 12.68