HitPredict

Interactor 1: H2B1J (P06899)
Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r)
Gene: H2BC11

Interactor 2: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34349018, 35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0046982 - protein heterodimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 1531
+	Hs
		542544 H2B2F_HUMAN (1-126): 2.18e-54: 168: 96.83		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542335 H2B1O_HUMAN (1-126): 2.8e-54: 167: 98.41		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		256754 H2B1K_HUMAN (1-126): 1.27e-53: 166: 99.21		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542404 H2BFS_HUMAN (1-126): 9.55e-54: 166: 97.62		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542433 H2B1C_HUMAN (1-126): 1.04e-53: 166: 98.41		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542536 H2B2E_HUMAN (1-126): 5.71e-54: 166: 99.21		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542605 H2B1H_HUMAN (1-126): 5.65e-54: 166: 97.62		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542627 H2B1N_HUMAN (1-126): 2.89e-53: 165: 97.62		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542405 H2B1D_HUMAN (1-126): 3.08e-53: 164: 97.62		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		542629 H2B1L_HUMAN (1-126): 2.37e-52: 163: 96.83		TOP2A_HUMAN (1-1531): 0: 1754: 100.00
+	Hs
		1039510 H2B2E_HUMAN (1-126): 5.71e-54: 166: 99.21		TOP2B_HUMAN (14-1523): 0: 1648: 65.78
+	Hs
		256837 H2B1K_HUMAN (1-126): 1.27e-53: 166: 99.21		TOP2B_HUMAN (14-1523): 0: 1648: 65.78
+	Hs
		980707 H2B1C_HUMAN (1-126): 1.04e-53: 166: 98.41		TOP2B_HUMAN (14-1523): 0: 1648: 65.78
+	Sc
		381359 H2B2_YEAST (3-125): 8.57e-37: 123: 70.73		TOP2_YEAST (24-1404): 0: 1259: 41.63
+	Sc
		380919 H2B1_YEAST (3-125): 2.76e-36: 122: 70.73		TOP2_YEAST (24-1404): 0: 1259: 41.63