HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: H2B1O (P23527)
Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)
Gene: H2BC17

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046982 - protein heterodimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 126
+	Hs
		542544 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B2F_HUMAN (1-126): 1.28e-55: 171: 98.41
+	Hs
		449669 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B1J_HUMAN (1-126): 5.51e-55: 169: 98.41
+	Hs
		542404 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2BFS_HUMAN (1-126): 8.83e-55: 169: 96.03
+	Hs
		542433 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B1C_HUMAN (1-126): 7.91e-55: 169: 98.41
+	Hs
		542536 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B2E_HUMAN (1-126): 4.94e-55: 169: 99.21
+	Hs
		542605 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B1H_HUMAN (1-126): 3.4e-55: 169: 99.21
+	Hs
		256754 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B1K_HUMAN (1-126): 1.05e-54: 168: 97.62
+	Hs
		542405 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B1D_HUMAN (1-126): 2.26e-54: 168: 97.62
+	Hs
		542627 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B1N_HUMAN (1-126): 2.24e-54: 168: 97.62
+	Hs
		542629 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H2B1L_HUMAN (1-126): 2.07e-53: 165: 96.83
+	Hs
		1039510 TOP2B_HUMAN (14-1523): 0: 1648: 65.78		H2B2E_HUMAN (1-126): 4.94e-55: 169: 99.21
+	Hs
		980707 TOP2B_HUMAN (14-1523): 0: 1648: 65.78		H2B1C_HUMAN (1-126): 7.91e-55: 169: 98.41
+	Hs
		256837 TOP2B_HUMAN (14-1523): 0: 1648: 65.78		H2B1K_HUMAN (1-126): 1.05e-54: 168: 97.62
+	Sc
		381359 TOP2_YEAST (24-1404): 0: 1259: 41.63		H2B2_YEAST (3-125): 3.1e-41: 134: 71.55
+	Sc
		380919 TOP2_YEAST (24-1404): 0: 1259: 41.63		H2B1_YEAST (4-125): 8.03e-37: 123: 72.13