HitPredict

Interactor 1: H2B1K (O60814)
Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)
Gene: H2BC12

Interactor 2: TOP2B (Q02880)
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
Gene: TOP2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 1626
+	Hs
		1039510 H2B2E_HUMAN (1-126): 5.57e-54: 166: 98.41		TOP2B_HUMAN (1-1626): 0: 1794: 100.00
+	Hs
		980707 H2B1C_HUMAN (1-126): 1.08e-53: 166: 99.21		TOP2B_HUMAN (1-1626): 0: 1794: 100.00
+	Hs
		542544 H2B2F_HUMAN (1-126): 2.2e-54: 168: 97.62		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542335 H2B1O_HUMAN (1-126): 2.89e-54: 167: 97.62		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		256754 H2B1K_HUMAN (1-126): 1.2e-53: 166: 100.00		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		449669 H2B1J_HUMAN (1-126): 6.15e-54: 166: 99.21		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542404 H2BFS_HUMAN (1-126): 9.85e-54: 166: 98.41		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542433 H2B1C_HUMAN (1-126): 1.08e-53: 166: 99.21		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542536 H2B2E_HUMAN (1-126): 5.57e-54: 166: 98.41		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542605 H2B1H_HUMAN (1-126): 5.45e-54: 166: 98.41		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542627 H2B1N_HUMAN (1-126): 2.98e-53: 165: 98.41		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542405 H2B1D_HUMAN (1-126): 3.18e-53: 164: 98.41		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Hs
		542629 H2B1L_HUMAN (1-126): 2.19e-52: 163: 97.62		TOP2A_HUMAN (33-1617): 0: 1627: 66.50
+	Sc
		381359 H2B2_YEAST (3-125): 7.28e-37: 123: 70.73		TOP2_YEAST (44-1445): 0: 1262: 41.29
+	Sc
		380919 H2B1_YEAST (3-125): 3.01e-36: 122: 70.73		TOP2_YEAST (44-1445): 0: 1262: 41.29
+	Hs
		814778 H2B1C_HUMAN (1-126): 1.08e-53: 166: 99.21		CUX1_HUMAN (894-1593): 3.36e-40: 165: 11.84
+	Hs
		754748 H2B1B_HUMAN (1-126): 1.53e-53: 165: 96.83		CUX1_HUMAN (894-1593): 3.36e-40: 165: 11.84