HitPredict

Interactor 1: WEE1 (P07527)
Mitosis inhibitor protein kinase wee1 (EC 2.7.10.2) (P107 protein kinase homolog)
Gene: WEE1

Interactor 2: HSP90 (P41887)
Heat shock protein 90 homolog
Gene: swo1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	11298745, 7813446
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 877 Sp			1 704
+	Hs
		468041 KPCA_HUMAN (407-872): 7.9e-123: 388: 15.78		HS90B_HUMAN (6-704): 0: 1015: 62.13
+	Hs
		468111 AKT2_HUMAN (451-871): 8.93e-125: 386: 16.17		HS90B_HUMAN (6-704): 0: 1015: 62.13
+	Hs
		468928 AKT3_HUMAN (448-871): 8.56e-125: 386: 18.08		HS90B_HUMAN (6-704): 0: 1015: 62.13
+	Mm
		547236 AKT1_MOUSE (451-871): 7.21e-124: 384: 18.57		HS90B_MOUSE (6-704): 0: 1017: 62.69
+	Bt
		1030112 AKT1_BOVIN (451-871): 2.21e-124: 385: 17.90		HS90B_BOVIN (6-704): 0: 1015: 62.27
+	Hs
		468110 AKT1_HUMAN (451-871): 7.44e-124: 384: 18.57		HS90B_HUMAN (6-704): 0: 1015: 62.13
+	Hs
		461120 KPCA_HUMAN (407-872): 7.9e-123: 388: 15.78		HS90A_HUMAN (3-704): 0: 1008: 62.17
+	Hs
		461428 PAK1_HUMAN (238-863): 2.13e-124: 388: 15.76		HS90A_HUMAN (3-704): 0: 1008: 62.17
+	Hs
		461191 AKT2_HUMAN (451-871): 8.93e-125: 386: 16.17		HS90A_HUMAN (3-704): 0: 1008: 62.17
+	Hs
		462058 AKT3_HUMAN (448-871): 8.56e-125: 386: 18.08		HS90A_HUMAN (3-704): 0: 1008: 62.17
+	Rn
		866337 AKT1_RAT (451-871): 8.46e-124: 384: 18.57		HS90A_RAT (3-704): 0: 1009: 62.36
+	Hs
		461190 AKT1_HUMAN (451-871): 7.44e-124: 384: 18.57		HS90A_HUMAN (3-704): 0: 1008: 62.17
+	Mm
		462100 AKT1_MOUSE (451-871): 7.21e-124: 384: 18.57		HS90A_MOUSE (3-704): 0: 1007: 62.36
+	Ca
		857778 Q5ANK2_CANAL (123-873): 5.3e-124: 403: 15.20		HSP90_CANAL (2-704): 0: 942: 72.91
+	Sc
		579972 STE20_YEAST (117-853): 1.81e-127: 408: 16.79		HSC82_YEAST (5-704): 0: 933: 72.83
+	Sc
		393118 FPK1_YEAST (151-860): 1.54e-121: 391: 16.16		HSP82_YEAST (4-704): 0: 930: 71.47
+	Sc
		548876 SCH9_YEAST (162-871): 4.22e-120: 385: 14.77		HSC82_YEAST (5-704): 0: 933: 72.83
+	Sc
		392110 SCH9_YEAST (162-871): 4.22e-120: 385: 14.77		HSP82_YEAST (4-704): 0: 930: 71.47
+	Hs
		573315 KPCA_HUMAN (407-872): 7.9e-123: 388: 15.78		ENPL_HUMAN (3-680): 0: 913: 48.91
+	Hs
		573725 AKT3_HUMAN (448-871): 8.56e-125: 386: 18.08		ENPL_HUMAN (3-680): 0: 913: 48.91