HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~RBD, PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0030335 - positive regulation of cell migration GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 1591
+	Hs
		463644 LYN_HUMAN (1-512): 0: 621: 100.00		ARG28_HUMAN (647-1544): 1.44e-116: 407: 12.82
+	Hs
		440455 FYN_HUMAN (1-510): 0: 583: 54.31		VAV2_HUMAN (949-1591): 5.83e-99: 341: 14.61
+	Hs
		463538 LYN_HUMAN (1-512): 0: 621: 100.00		ITSN1_HUMAN (990-1425): 4.7e-76: 282: 18.04
+	Hs
		439933 LCK_HUMAN (1-512): 0: 585: 63.62		VAV_HUMAN (954-1591): 8.61e-89: 311: 15.22
+	Hs
		440335 FYN_HUMAN (1-510): 0: 583: 54.31		VAV_HUMAN (954-1591): 8.61e-89: 311: 15.22
+	Hs
		557253 SRC_HUMAN (1-510): 0: 591: 51.97		SOS2_HUMAN (1023-1575): 2.64e-75: 278: 13.76
+	Hs
		440576 FYN_HUMAN (1-510): 0: 583: 54.31		ITSN1_HUMAN (990-1425): 4.7e-76: 282: 18.04
+	Hs
		440512 FYN_HUMAN (1-510): 0: 583: 54.31		SOS2_HUMAN (1023-1575): 2.64e-75: 278: 13.76
+	Hs
		299507 LYN_HUMAN (1-512): 0: 621: 100.00		TRIO_HUMAN (1029-1589): 3.2e-60: 231: 16.29
+	Hs
		362147 ABL1_HUMAN (32-509): 1.52e-174: 523: 37.88		VAV_HUMAN (954-1591): 8.61e-89: 311: 15.22
+	Hs
		238795 LCK_HUMAN (1-512): 0: 585: 63.62		KALRN_HUMAN (996-1589): 4.11e-65: 247: 17.29
+	Hs
		238796 FYN_HUMAN (1-510): 0: 583: 54.31		KALRN_HUMAN (996-1589): 4.11e-65: 247: 17.29
+	Hs
		299505 LCK_HUMAN (1-512): 0: 585: 63.62		TRIO_HUMAN (1029-1589): 3.2e-60: 231: 16.29
+	Hs
		362263 ABL1_HUMAN (32-509): 1.52e-174: 523: 37.88		SOS2_HUMAN (1023-1575): 2.64e-75: 278: 13.76
+	Hs
		584487 TEC_HUMAN (35-505): 1.07e-162: 477: 35.27		VAV_HUMAN (954-1591): 8.61e-89: 311: 15.22
+	Hs
		584523 BTK_HUMAN (26-505): 7.72e-159: 468: 35.15		VAV_HUMAN (954-1591): 8.61e-89: 311: 15.22