HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: ROS1 (P08922)
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Gene: ROS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38334954
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 2347
+	Hs
		468217 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHB1_HUMAN (1380-2290): 0: 616: 19.24
+	Hs
		468218 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHA4_HUMAN (1385-2321): 0: 614: 19.22
+	Hs
		468876 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHA6_HUMAN (1367-2290): 0: 593: 19.02
+	Hs
		468100 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHA2_HUMAN (1381-2290): 2.45e-168: 547: 20.15
+	Hs
		465366 HS90B_HUMAN (1-724): 0: 1083: 100.00		IGF1R_HUMAN (1442-2307): 3.32e-163: 544: 22.98
+	Hs
		461043 HS90A_HUMAN (1-724): 0: 1069: 85.25		IGF1R_HUMAN (1442-2307): 3.32e-163: 544: 22.98
+	Hs
		468023 HS90B_HUMAN (1-724): 0: 1083: 100.00		INSRR_HUMAN (1442-2261): 1.19e-155: 520: 24.39
+	Hs
		468066 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHA1_HUMAN (1385-2275): 4.78e-159: 520: 18.89
+	Hs
		468294 HS90B_HUMAN (1-724): 0: 1083: 100.00		TYRO3_HUMAN (1514-2218): 6.64e-147: 483: 23.67
+	Hs
		468105 HS90B_HUMAN (1-724): 0: 1083: 100.00		UFO_HUMAN (1633-2297): 3.66e-130: 435: 25.83
+	Hs
		468913 HS90B_HUMAN (1-724): 0: 1083: 100.00		ALK_HUMAN (1858-2311): 4.33e-84: 309: 38.96
+	Hs
		463881 HS90B_HUMAN (1-724): 0: 1083: 100.00		RET_HUMAN (1940-2216): 6.43e-64: 241: 42.76
+	Hs
		468037 HS90B_HUMAN (1-724): 0: 1083: 100.00		FER_HUMAN (1943-2219): 4.92e-62: 231: 41.88
+	Hs
		456084 HS90B_HUMAN (1-724): 0: 1083: 100.00		FES_HUMAN (1943-2219): 1.12e-60: 227: 42.60
+	Hs
		461040 HS90A_HUMAN (1-724): 0: 1069: 85.25		RET_HUMAN (1940-2216): 6.43e-64: 241: 42.76
+	Hs
		468073 HS90B_HUMAN (1-724): 0: 1083: 100.00		FGFR3_HUMAN (1886-2215): 4.24e-59: 222: 38.73
+	Hs
		440303 HS90B_HUMAN (1-724): 0: 1083: 100.00		FYN_HUMAN (1941-2216): 4.38e-59: 216: 43.12
+	Hs
		468013 HS90B_HUMAN (1-724): 0: 1083: 100.00		SRC_HUMAN (1941-2216): 1.14e-58: 214: 43.12
+	Hs
		456083 HS90A_HUMAN (1-724): 0: 1069: 85.25		FES_HUMAN (1943-2219): 1.12e-60: 227: 42.60
+	Hs
		440299 HS90A_HUMAN (1-724): 0: 1069: 85.25		FYN_HUMAN (1941-2216): 4.38e-59: 216: 43.12