HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 499
+	Hs
		461273 HS90A_HUMAN (1-724): 0: 1069: 85.25		CLK2_HUMAN (1-499): 6.98e-147: 431: 100.00
+	Hs
		468183 HS90B_HUMAN (1-724): 0: 1083: 100.00		CLK3_HUMAN (1-499): 4.5e-133: 395: 59.32
+	Hs
		468087 HS90B_HUMAN (1-724): 0: 1083: 100.00		CDK2_HUMAN (160-488): 2.04e-132: 387: 24.70
+	Hs
		461274 HS90A_HUMAN (1-724): 0: 1069: 85.25		CLK3_HUMAN (1-499): 4.5e-133: 395: 59.32
+	Hs
		461165 HS90A_HUMAN (1-724): 0: 1069: 85.25		CDK2_HUMAN (160-488): 2.04e-132: 387: 24.70
+	Hs
		468267 HS90B_HUMAN (1-724): 0: 1083: 100.00		CDK3_HUMAN (160-495): 8.2e-125: 368: 24.20
+	Hs
		461361 HS90A_HUMAN (1-724): 0: 1069: 85.25		CDK3_HUMAN (160-495): 8.2e-125: 368: 24.20
+	Hs
		468658 HS90B_HUMAN (1-724): 0: 1083: 100.00		DYRK2_HUMAN (9-499): 2.12e-115: 354: 22.35
+	Hs
		468834 HS90B_HUMAN (1-724): 0: 1083: 100.00		DYRK4_HUMAN (128-495): 4e-113: 345: 29.35
+	Hs
		468948 HS90B_HUMAN (1-724): 0: 1083: 100.00		DYR1B_HUMAN (108-488): 3.01e-110: 341: 29.03
+	Hs
		461774 HS90A_HUMAN (1-724): 0: 1069: 85.25		DYRK2_HUMAN (9-499): 2.12e-115: 354: 22.35
+	Hs
		461961 HS90A_HUMAN (1-724): 0: 1069: 85.25		DYRK4_HUMAN (128-495): 4e-113: 345: 29.35
+	Hs
		468356 HS90B_HUMAN (1-724): 0: 1083: 100.00		DYR1A_HUMAN (108-485): 8.54e-105: 331: 28.50
+	Hs
		462077 HS90A_HUMAN (1-724): 0: 1069: 85.25		DYR1B_HUMAN (108-488): 3.01e-110: 341: 29.03
+	Hs
		443124 HS90A_HUMAN (1-724): 0: 1069: 85.25		CDK1_HUMAN (160-483): 1.01e-113: 339: 24.10
+	Hs
		461459 HS90A_HUMAN (1-724): 0: 1069: 85.25		DYR1A_HUMAN (108-485): 8.54e-105: 331: 28.50
+	Hs
		573334 ENPL_HUMAN (3-693): 0: 914: 46.44		CDK2_HUMAN (160-488): 2.04e-132: 387: 24.70
+	Ca
		845371 HSP90_CANAL (8-724): 0: 927: 60.42		CDK1_CANAL (160-479): 8.58e-112: 335: 23.40
+	Sp
		410445 HSP90_SCHPO (10-724): 0: 926: 62.48		CDK1_SCHPO (160-483): 5.07e-112: 335: 23.35
+	Hs
		889748 H90B3_HUMAN (1-724): 0: 815: 75.83		CLK3_HUMAN (1-499): 4.5e-133: 395: 59.32