Protein: ACVL1
Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I)

Gene: ACVL1, ACVRL1
Organism: Homo sapiens
Interactions: 40
UniProt ID: P37023

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001701 - in utero embryonic development
GO:0001936 - regulation of endothelial cell proliferation
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788457

ACVR1
Activin receptor type-1

3

19

High-throughput

0.861

High

788450

TGFR2
TGF-beta receptor type-2

3

20

Small-scale

0.847

High

787356

TGFR1
TGF-beta receptor type-1

2

19

Small-scale

0.776

High

690074

AVR2A
Activin receptor type-2A

2

20

Small-scale

0.754

High

608228

EGLN
Endoglin

6

12

Small-scale

0.730

High

376740

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

4

20

Small-scale

0.676

High

788467

GDF2
Growth/differentiation factor 2

3

20

Small-scale

0.655

High

388859

A2GL
Leucine-rich alpha-2-glycoprotein

1

20

Small-scale

0.646

High

461224

HS90A
Heat shock protein HSP 90-alpha

1

16

Small-scale

0.618

High

658855

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

6

Small-scale

0.618

High

788460

SMAD1
Mothers against decapentaplegic homolog 1

2

20

Small-scale

0.602

High

788452

NR1H2
Oxysterols receptor LXR-beta

1

2

Small-scale

0.586

High

788453

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

7

Small-scale

0.555

High

788463

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.552

High

788454

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.549

High

788456

TGBR3
Transforming growth factor beta receptor type 3

1

12

Small-scale

0.515

High

788458

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

5

Small-scale

0.501

High

788461

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

2

High-throughput

0.489

High

424155

S10A8
Protein S100-A8

1

2

Small-scale

0.479

High

444922

S10A9
Protein S100-A9

1

2

Small-scale

0.479

High

470366

INHBA
Inhibin beta A chain

1

20

Small-scale

0.479

High

473670

ITA5
Integrin alpha-5

1

4

Small-scale

0.479

High

507621

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

528389

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

1

20

Small-scale

0.479

High

633359

MX1
Interferon-induced GTP-binding protein Mx1

1

1

Small-scale

0.479

High

788455

CAV1
Caveolin-1

1

6

Small-scale

0.479

High

788459

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.479

High

788464

IGSF1
Immunoglobulin superfamily member 1

1

7

Small-scale

0.479

High

788469

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

15

Small-scale

0.479

High

721493

ILEU
Leukocyte elastase inhibitor

1

0

Small-scale

0.458

High

788466

GSDMA
Gasdermin-A

1

0

Small-scale

0.458

High

682458

S100P
Protein S100-P

1

2

Small-scale

0.437

High

698445

CALX
Calnexin

1

8

Small-scale

0.437

High

788468

SNX6
Sorting nexin-6

1

8

Small-scale

0.437

High

788462

PDXD2
Putative pyridoxal-dependent decarboxylase domain-containing protein 2

2

0

High-throughput

0.298

High

445505

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.292

High

788465

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

Small-scale

0.261

Low

613672

GPX2
Glutathione peroxidase 2

1

0

Small-scale

0.249

Low

729519

CASPE
Caspase-14

1

0

Small-scale

0.249

Low

788451

TALDO
Transaldolase

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025