HitPredict

Interactor 1: NFIC (P08651)
Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Gene: NFIC

Interactor 2: TBL1R (Q9BZK7)
F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)
Gene: TBL1XR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35140242, 39617063
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 514
+	Hs
		1133643 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		TBL1R_HUMAN (1-514): 4.97e-163: 473: 100.00
+	Hs
		261359 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		TBL1X_HUMAN (1-514): 6.19e-151: 445: 86.34
+	Hs
		261410 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		TBL1X_HUMAN (1-514): 6.19e-151: 445: 86.34
+	Hs
		1087992 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		TBL1R_HUMAN (1-514): 4.97e-163: 473: 100.00
+	Hs
		143235 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		TBL1R_HUMAN (1-514): 4.97e-163: 473: 100.00
+	Hs
		261401 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		TBL1X_HUMAN (1-514): 6.19e-151: 445: 86.34
+	Hs
		142745 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		TBL1X_HUMAN (1-514): 6.19e-151: 445: 86.34
+	Hs
		473949 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		TBL3_HUMAN (131-514): 7.25e-55: 198: 15.21
+	Hs
		474198 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		SNR40_HUMAN (62-195): 5.26e-12: 69.1: 11.51
+	Hs
		1133422 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		TAF5_HUMAN (164-376): 6.25e-14: 76.6: 23.72
+	Hs
		1087935 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		SNR40_HUMAN (62-195): 5.26e-12: 69.1: 11.51
+	Hs
		787890 SRBP1_HUMAN (293-455): 4.45e-21: 99.2: 15.06		FBXW7_HUMAN (68-423): 1.43e-69: 237: 16.34
+	Hs
		667395 RPB1_HUMAN (374-496): 2.4e-09: 62.2: 20.33		FBXW7_HUMAN (68-423): 1.43e-69: 237: 16.34
+	Hs
		597339 RPB1_HUMAN (374-496): 2.4e-09: 62.2: 20.33		GBB3_HUMAN (197-510): 6.05e-61: 205: 19.20
+	Hs
		965301 RERE_HUMAN (185-495): 5.5e-30: 126: 13.87		WDR5_HUMAN (434-513): 1.45e-19: 91.8: 32.10
+	Mm
		965395 KMT2C_MOUSE (155-502): 3.72e-09: 61.9: 9.12		WDR5_MOUSE (434-513): 1.45e-19: 91.8: 32.10
+	Mm
		476218 RPB1_MOUSE (375-496): 7.88e-09: 60.7: 19.67		WDR5_MOUSE (434-513): 1.45e-19: 91.8: 32.10
+	Hs
		965097 KMT2C_HUMAN (177-499): 7.46e-09: 60.7: 11.98		WDR5_HUMAN (434-513): 1.45e-19: 91.8: 32.10