HitPredict

Interactor 1: ITB1 (P09055)
Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29)
Gene: Itgb1

Interactor 2: TLN1 (P26039)
Talin-1
Gene: TLN1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	30333137, 21947080
Identification Methods	pull down, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IRS~Integrin_b_cyt
Common GO terms	GO:0005178 - integrin binding GO:0005925 - focal adhesion GO:0007229 - integrin-mediated signaling pathway GO:0009986 - cell surface GO:0032587 - ruffle membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 798 Mm			1 2541
+	Rn
		108177 ITB1_RAT (1-798): 0: 819: 98.00		G3V852_RAT (1-2541): 0: 1249: 99.37
+	Hs
		431942 ITB1_HUMAN (1-798): 0: 820: 92.48		TLN1_HUMAN (1-2541): 0: 1248: 98.74
+	Mm
		236559 ITB3_MOUSE (23-797): 0: 684: 44.16		TLN1_MOUSE (1-2541): 0: 1253: 100.00
+	Hs
		424047 ITB3_HUMAN (25-797): 0: 656: 43.89		TLN1_HUMAN (1-2541): 0: 1248: 98.74
+	Mm
		549376 ITB2_MOUSE (21-796): 0: 645: 45.84		TLN1_MOUSE (1-2541): 0: 1253: 100.00
+	Hs
		424110 ITB2_HUMAN (20-796): 0: 683: 45.07		TLN2_HUMAN (1-2541): 0: 1214: 75.87
+	Hs
		612130 ITB5_HUMAN (25-789): 0: 679: 42.49		TLN2_HUMAN (1-2541): 0: 1214: 75.87
+	Hs
		431686 ITB1_HUMAN (1-798): 0: 820: 92.48		EZRI_HUMAN (84-650): 2.74e-83: 288: 14.41
+	Hs
		431729 ITB1_HUMAN (1-798): 0: 820: 92.48		RADI_HUMAN (163-404): 5.4e-57: 211: 22.27
+	Hs
		431847 ITB1_HUMAN (1-798): 0: 820: 92.48		URP2_HUMAN (200-416): 1.03e-51: 197: 23.74
+	Mm
		478561 ITB1_MOUSE (1-798): 0: 826: 100.00		PLEC_MOUSE (1455-2500): 4.96e-22: 107: 12.19
+	Mm
		478543 ITB1_MOUSE (1-798): 0: 826: 100.00		FERM2_MOUSE (268-416): 3.41e-11: 70.9: 28.48
+	Hs
		424061 ITB2_HUMAN (20-796): 0: 683: 45.07		RADI_HUMAN (163-404): 5.4e-57: 211: 22.27
+	Hs
		431867 ITB1_HUMAN (1-798): 0: 820: 92.48		FERM2_HUMAN (268-416): 1.73e-11: 72: 27.82
+	Rn
		879687 ITB1_RAT (1-798): 0: 819: 98.00		Q5XI19_RAT (268-416): 3.36e-11: 70.9: 28.48
+	Hs
		431888 ITB1_HUMAN (1-798): 0: 820: 92.48		FERM1_HUMAN (268-422): 4.76e-09: 63.9: 24.20
+	Hs
		424039 ITB3_HUMAN (25-797): 0: 656: 43.89		URP2_HUMAN (200-416): 1.03e-51: 197: 23.74
+	Mm
		236641 ITB3_MOUSE (23-797): 0: 684: 44.16		PLEC_MOUSE (1455-2500): 4.96e-22: 107: 12.19
+	Mm
		266860 ITB5_MOUSE (9-789): 0: 676: 42.01		MYO7A_MOUSE (83-382): 8.06e-17: 90.3: 18.91
+	Hs
		612106 ITB5_HUMAN (25-789): 0: 679: 42.49		FERM2_HUMAN (268-416): 1.73e-11: 72: 27.82