HitPredict

Interactor 1: SCR (P09077)
Homeotic protein Sex combs reduced
Gene: SCR

Interactor 2: EXD (P40427)
Homeobox protein extradenticle (Dpbx)
Gene: EXD

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	22564794, 17981120, 22745600, 30802457, unassigned4
Identification Methods	affinity chromatography technology, x-ray crystallography, protein complementation assay, pull down, bimolecular fluorescence complementation, experimental interaction detection
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0007432 - salivary gland boundary specification GO:0043565 - sequence-specific DNA binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 417 Dm			1 376
+	Dm
		652140 TIN_DROME (93-403): 1.25e-40: 151: 18.93		EXD_DROME (1-376): 6.5e-115: 340: 100.00
+	Dm
		458216 DFD_DROME (304-389): 4.87e-36: 141: 66.29		EXD_DROME (1-376): 6.5e-115: 340: 100.00
+	Dm
		393627 ANTP_DROME (95-404): 1.33e-35: 136: 36.05		EXD_DROME (1-376): 6.5e-115: 340: 100.00
+	Mm
		204667 HXB8_MOUSE (234-391): 9.08e-36: 133: 36.81		PBX3_MOUSE (1-368): 4.22e-100: 305: 67.38
+	Mm
		204668 HXD4_MOUSE (209-389): 2.85e-35: 132: 43.17		PBX3_MOUSE (1-368): 4.22e-100: 305: 67.38
+	Mm
		484850 HXB8_MOUSE (234-391): 9.08e-36: 133: 36.81		PBX1_MOUSE (2-375): 1.96e-99: 303: 68.72
+	Hs
		574042 HXB1_HUMAN (160-406): 4.2e-35: 133: 27.80		PBX1_HUMAN (2-375): 1.96e-99: 303: 68.72
+	Hs
		478283 HXD4_HUMAN (205-389): 3.48e-35: 132: 41.71		PBX1_HUMAN (2-375): 1.96e-99: 303: 68.72
+	Mm
		528899 HXD4_MOUSE (209-389): 2.85e-35: 132: 43.17		PBX1_MOUSE (2-375): 1.96e-99: 303: 68.72
+	Mm
		204664 HXB5_MOUSE (179-395): 8.75e-34: 128: 33.64		PBX3_MOUSE (1-368): 4.22e-100: 305: 67.38
+	Mm
		204672 HXC5_MOUSE (203-389): 7.96e-34: 127: 41.27		PBX3_MOUSE (1-368): 4.22e-100: 305: 67.38
+	Hs
		478660 HXB5_HUMAN (179-395): 4.91e-34: 129: 33.64		PBX1_HUMAN (2-375): 1.96e-99: 303: 68.72
+	Mm
		478353 HXB6_MOUSE (198-393): 4.51e-34: 128: 38.27		PBX1_MOUSE (2-375): 1.96e-99: 303: 68.72
+	Mm
		732020 HXC5_MOUSE (203-389): 7.96e-34: 127: 41.27		PBX1_MOUSE (2-375): 1.96e-99: 303: 68.72
+	Hs
		604772 HXB8_HUMAN (193-392): 4.67e-33: 126: 31.71		PBX1_HUMAN (2-375): 1.96e-99: 303: 68.72
+	Hs
		478300 HXD4_HUMAN (205-389): 3.48e-35: 132: 41.71		PBX4_HUMAN (42-376): 5.41e-97: 295: 63.93
+	Hs
		478721 HXB5_HUMAN (179-395): 4.91e-34: 129: 33.64		PBX4_HUMAN (42-376): 5.41e-97: 295: 63.93
+	Hs
		478661 HXB5_HUMAN (179-395): 4.91e-34: 129: 33.64		PBX2_HUMAN (40-368): 3.36e-90: 279: 72.64
+	Mm
		484856 HXB8_MOUSE (234-391): 9.08e-36: 133: 36.81		MEIS1_MOUSE (3-339): 4.18e-65: 213: 16.75
+	Mm
		484858 HXB8_MOUSE (234-391): 9.08e-36: 133: 36.81		PKNX2_MOUSE (180-360): 5.81e-34: 132: 22.65