HitPredict

Interactor 1: HXB8 (P09632)
Homeobox protein Hox-B8 (Homeobox protein Hox-2.4)
Gene: Hoxb8

Interactor 2: MEIS1 (Q60954)
Homeobox protein Meis1 (Myeloid ecotropic viral integration site 1)
Gene: MEIS1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	1.00	0.730

Property	Details
Experiments	20211142, 15617687
Identification Methods	two hybrid array, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0005654 - nucleoplasm GO:0043565 - sequence-specific DNA binding GO:0045638 - negative regulation of myeloid cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Mm			1 390
+	Mm
		999937 HXD13_MOUSE (4-213): 2.47e-36: 132: 25.54		MEIS1_MOUSE (1-390): 7.94e-139: 402: 100.00
+	Mm
		484858 HXB8_MOUSE (1-243): 1.95e-60: 192: 100.00		PKNX2_MOUSE (1-376): 1.75e-80: 256: 35.47
+	Dm
		235194 ABDA_DROME (143-230): 4.69e-38: 141: 60.23		HTH_DROME (1-389): 3.22e-87: 274: 47.00
+	Mm
		479042 HXA6_MOUSE (1-223): 8.53e-41: 141: 32.04		PKNX2_MOUSE (1-376): 1.75e-80: 256: 35.47
+	Hs
		604773 HXB8_HUMAN (1-243): 6.37e-62: 195: 98.35		PBX3_HUMAN (6-390): 8.82e-52: 180: 15.71
+	Mm
		204667 HXB8_MOUSE (1-243): 1.95e-60: 192: 100.00		PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71
+	Hs
		725109 HXC8_HUMAN (1-214): 1.32e-43: 149: 58.99		PBX4_HUMAN (43-363): 2.16e-52: 180: 16.81
+	Mm
		204665 HXA6_MOUSE (1-223): 8.53e-41: 141: 32.04		PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71
+	Mm
		204672 HXC5_MOUSE (1-213): 4.58e-37: 131: 30.18		PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71
+	Hs
		1025226 HXC5_HUMAN (1-213): 7.67e-36: 128: 26.13		PBX4_HUMAN (43-363): 2.16e-52: 180: 16.81
+	Mm
		204668 HXD4_MOUSE (1-228): 1.05e-35: 128: 27.16		PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71
+	Hs
		478300 HXD4_HUMAN (1-206): 1.21e-35: 128: 29.58		PBX4_HUMAN (43-363): 2.16e-52: 180: 16.81
+	Mm
		204669 HXC6_MOUSE (1-204): 4.41e-35: 126: 32.20		PBX3_MOUSE (6-390): 1.26e-51: 180: 15.71
+	Dm
		713681 ABDA_DROME (143-230): 4.69e-38: 141: 60.23		Q7JR08_DROME (203-388): 8.48e-41: 151: 25.13
+	Dm
		478764 SCR_DROME (108-206): 8.74e-40: 143: 50.47		EXD_DROME (223-388): 2.82e-39: 146: 24.85
+	Dm
		713650 ABDA_DROME (143-230): 4.69e-38: 141: 60.23		EXD_DROME (223-388): 2.82e-39: 146: 24.85
+	Dm
		458216 DFD_DROME (101-229): 6.14e-37: 138: 39.29		EXD_DROME (223-388): 2.82e-39: 146: 24.85
+	Hs
		725026 HXC8_HUMAN (1-214): 1.32e-43: 149: 58.99		PBX2_HUMAN (273-372): 1.6e-28: 117: 34.19
+	Hs
		823878 HXC5_HUMAN (1-213): 7.67e-36: 128: 26.13		PBX2_HUMAN (273-372): 1.6e-28: 117: 34.19
+	Hs
		823875 GSC_HUMAN (7-242): 5.83e-35: 127: 17.93		PBX2_HUMAN (273-372): 1.6e-28: 117: 34.19