HitPredict

Interactor 1: HXB8 (P09632)
Homeobox protein Hox-B8 (Homeobox protein Hox-2.4)
Gene: Hoxb8

Interactor 2: PBX1 (P41778)
Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1)
Gene: PBX1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	20211142, 22745600
Identification Methods	two hybrid, bimolecular fluorescence complementation, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0005654 - nucleoplasm GO:0009952 - anterior/posterior pattern specification GO:0043565 - sequence-specific DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Mm			1 430
+	Hs
		604772 HXB8_HUMAN (1-243): 6.37e-62: 195: 98.35		PBX1_HUMAN (1-430): 2.7e-149: 432: 100.00
+	Hs
		604773 HXB8_HUMAN (1-243): 6.37e-62: 195: 98.35		PBX3_HUMAN (1-430): 1.27e-142: 416: 81.32
+	Mm
		204667 HXB8_MOUSE (1-243): 1.95e-60: 192: 100.00		PBX3_MOUSE (1-430): 5.28e-142: 414: 81.55
+	Hs
		725025 HXC8_HUMAN (1-214): 1.32e-43: 149: 58.99		PBX1_HUMAN (1-430): 2.7e-149: 432: 100.00
+	Mm
		479040 HXA6_MOUSE (1-223): 8.53e-41: 141: 32.04		PBX1_MOUSE (1-430): 2.7e-149: 432: 100.00
+	Hs
		484820 HXB7_HUMAN (1-216): 4e-40: 139: 36.20		PBX1_HUMAN (1-430): 2.7e-149: 432: 100.00
+	Mm
		732020 HXC5_MOUSE (1-213): 4.58e-37: 131: 30.18		PBX1_MOUSE (1-430): 2.7e-149: 432: 100.00
+	Mm
		204665 HXA6_MOUSE (1-223): 8.53e-41: 141: 32.04		PBX3_MOUSE (1-430): 5.28e-142: 414: 81.55
+	Mm
		204672 HXC5_MOUSE (1-213): 4.58e-37: 131: 30.18		PBX3_MOUSE (1-430): 5.28e-142: 414: 81.55
+	Hs
		725026 HXC8_HUMAN (1-214): 1.32e-43: 149: 58.99		PBX2_HUMAN (40-430): 1.17e-116: 349: 80.87
+	Hs
		725109 HXC8_HUMAN (1-214): 1.32e-43: 149: 58.99		PBX4_HUMAN (42-430): 1.82e-110: 331: 65.13
+	Dm
		478764 SCR_DROME (108-206): 8.74e-40: 143: 50.47		EXD_DROME (3-344): 3.81e-107: 323: 74.07
+	Dm
		713650 ABDA_DROME (143-230): 4.69e-38: 141: 60.23		EXD_DROME (3-344): 3.81e-107: 323: 74.07
+	Dm
		458216 DFD_DROME (101-229): 6.14e-37: 138: 39.29		EXD_DROME (3-344): 3.81e-107: 323: 74.07
+	Mm
		484858 HXB8_MOUSE (1-243): 1.95e-60: 192: 100.00		PKNX2_MOUSE (175-375): 8.25e-41: 153: 21.78
+	Dm
		713681 ABDA_DROME (143-230): 4.69e-38: 141: 60.23		Q7JR08_DROME (153-429): 2.21e-54: 188: 18.57
+	Mm
		484856 HXB8_MOUSE (1-243): 1.95e-60: 192: 100.00		MEIS1_MOUSE (237-320): 6.86e-26: 109: 35.29
+	Mm
		479042 HXA6_MOUSE (1-223): 8.53e-41: 141: 32.04		PKNX2_MOUSE (175-375): 8.25e-41: 153: 21.78
+	Dm
		235194 ABDA_DROME (143-230): 4.69e-38: 141: 60.23		HTH_DROME (234-338): 1.72e-24: 107: 27.78
+	Mm
		999937 HXD13_MOUSE (4-213): 2.47e-36: 132: 25.54		MEIS1_MOUSE (237-320): 6.86e-26: 109: 35.29