HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: MSX2 (P35548)
Homeobox protein MSX-2 (Homeobox protein Hox-8)
Gene: MSX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35356984
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 267
+	Mm
		1000332 SOX8_MOUSE (7-86): 7.9e-22: 94.4: 18.75		DLX5_MOUSE (14-249): 4.51e-53: 175: 29.88
+	Hs
		186620 HMGB3_HUMAN (13-181): 1.46e-41: 141: 71.60		PAX6_HUMAN (1-263): 2.81e-32: 124: 17.46
+	Hs
		481050 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		HXC6_HUMAN (52-200): 2.22e-29: 112: 21.85
+	Dm
		1014407 Q9VUD3_DROME (2-95): 9.51e-28: 111: 21.28		UBX_DROME (4-203): 8.38e-33: 125: 23.79
+	Dm
		1042519 Q9VUD3_DROME (2-95): 9.51e-28: 111: 21.28		HMSH_DROME (120-212): 4e-31: 122: 79.57
+	Dm
		120138 M9PCG2_DROME (2-95): 1.49e-27: 110: 21.28		HMSH_DROME (120-212): 4e-31: 122: 79.57
+	Dm
		121513 M9PFG6_DROME (7-95): 1.32e-25: 104: 21.35		UBX_DROME (4-203): 8.38e-33: 125: 23.79
+	Dm
		120234 M9PCZ7_DROME (3-84): 1.09e-24: 103: 23.17		UBX_DROME (4-203): 8.38e-33: 125: 23.79
+	Hs
		685120 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		PAX6_HUMAN (1-263): 2.81e-32: 124: 17.46
+	Mm
		478349 Q60I23_MOUSE (3-94): 1.01e-24: 100: 23.91		HXA5_MOUSE (38-217): 2.27e-32: 121: 20.00
+	Hs
		634834 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		HXA5_HUMAN (38-217): 6.44e-32: 120: 20.56
+	Mm
		666049 SOX8_MOUSE (7-86): 7.9e-22: 94.4: 18.75		PAX3_MOUSE (12-258): 6.85e-32: 124: 20.70
+	Hs
		872735 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		ALX4_HUMAN (58-262): 4.07e-30: 118: 21.53
+	Ce
		1169673 SOX3_CAEEL (7-96): 9.23e-25: 98.2: 23.33		HM30_CAEEL (100-244): 6.21e-32: 119: 27.70
+	Hs
		662313 SOX10_HUMAN (4-98): 2.08e-21: 93.2: 14.74		PAX3_HUMAN (12-258): 1.02e-31: 123: 20.70
+	Hs
		634885 SOX17_HUMAN (7-90): 3.94e-22: 94.8: 19.05		HXA5_HUMAN (38-217): 6.44e-32: 120: 20.56
+	Hs
		604795 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		HXB9_HUMAN (7-207): 1.41e-29: 113: 21.68
+	Dm
		120139 M9PCG2_DROME (2-95): 1.49e-27: 110: 21.28		Q058W3_DROME (143-208): 1.23e-11: 65.9: 50.00
+	Dm
		652994 DICH_DROME (7-101): 9.28e-27: 107: 24.21		BAGP_DROME (143-217): 8.3e-12: 66.2: 49.33
+	Dm
		1052699 DICH_DROME (7-101): 9.28e-27: 107: 24.21		Q058W3_DROME (143-208): 1.23e-11: 65.9: 50.00