HitPredict

Interactor 1: MYCL (P12524)
Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog)
Gene: MYCL

Interactor 2: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	2006410, 29028833, 27705803, 10229200
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0046983 - protein dimerization activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 364 Hs			1 160
+	Mm
		486429 MYCL_MOUSE (1-364): 6.02e-110: 327: 88.86		MAX_MOUSE (1-160): 4.6e-32: 113: 99.38
+	Rn
		449464 MYC_RAT (1-362): 1.8e-78: 249: 29.98		MAX_RAT (1-160): 2.48e-32: 114: 98.75
+	Mm
		348406 MYC_MOUSE (1-362): 4.56e-78: 248: 29.98		MAX_MOUSE (1-160): 4.6e-32: 113: 99.38
+	Hs
		346390 MYC_HUMAN (1-362): 1e-76: 245: 29.75		MAX_HUMAN (1-160): 2.05e-31: 112: 100.00
+	Hs
		347688 MYC_HUMAN (1-362): 1e-76: 245: 29.75		MNT_HUMAN (7-150): 3.44e-26: 104: 24.84
+	Mm
		348399 MYC_MOUSE (1-362): 4.56e-78: 248: 29.98		MYCN_MOUSE (7-101): 8.72e-22: 92.3: 32.65
+	Hs
		345631 MYC_HUMAN (1-362): 1e-76: 245: 29.75		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		345658 MYC_HUMAN (1-362): 1e-76: 245: 29.75		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Gg
		348453 MYC_CHICK (2-362): 2.05e-69: 225: 29.33		MAX_CHICK (1-160): 3.42e-31: 111: 95.63
+	Mm
		372842 MYCN_MOUSE (1-362): 1.18e-66: 219: 31.18		MAX_MOUSE (1-160): 4.6e-32: 113: 99.38
+	Hs
		379188 MYCN_HUMAN (1-362): 2.43e-63: 210: 31.05		MAX_HUMAN (1-160): 2.05e-31: 112: 100.00
+	Hs
		378891 MYCN_HUMAN (1-362): 2.43e-63: 210: 31.05		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		738962 SRBP1_HUMAN (35-363): 5.77e-47: 173: 14.29		SRBP2_HUMAN (19-149): 1.42e-29: 114: 25.56
+	Hs
		1079719 USF2_HUMAN (46-362): 1.87e-51: 176: 19.76		USF2_HUMAN (16-115): 1.18e-24: 99.1: 29.91
+	Hs
		738941 SRBP1_HUMAN (35-363): 5.77e-47: 173: 14.29		SRBP1_HUMAN (9-149): 2.92e-25: 102: 20.00
+	Hs
		607822 USF2_HUMAN (46-362): 1.87e-51: 176: 19.76		USF1_HUMAN (10-115): 4.62e-23: 94.1: 30.97
+	Hs
		607791 SRBP1_HUMAN (35-363): 5.77e-47: 173: 14.29		USF1_HUMAN (10-115): 4.62e-23: 94.1: 30.97
+	Dm
		954686 Q8SY46_DROME (112-362): 2.2e-42: 157: 17.38		MAX_DROME (20-106): 6.37e-18: 77.6: 62.07