HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 594
+	Hs
		519772 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC1_HUMAN (3-593): 6.56e-176: 512: 47.06
+	Hs
		520146 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC4_HUMAN (1-592): 5.14e-158: 468: 43.68
+	Hs
		519975 ANDR_HUMAN (1-920): 0: 966: 100.00		BTK_HUMAN (312-593): 3.03e-48: 180: 14.47
+	Hs
		519699 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (361-594): 9.01e-49: 179: 17.79
+	Hs
		462956 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (355-594): 4.7e-48: 177: 17.31
+	Hs
		520123 ANDR_HUMAN (1-920): 0: 966: 100.00		SHE_HUMAN (348-593): 3.55e-47: 174: 22.53
+	Hs
		486651 ANDR_HUMAN (1-920): 0: 966: 100.00		FGR_HUMAN (359-594): 1.23e-46: 173: 18.22
+	Hs
		519814 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL2_HUMAN (342-592): 2.09e-44: 171: 15.91
+	Hs
		473353 ANDR_HUMAN (1-920): 0: 966: 100.00		HCK_HUMAN (360-594): 1.09e-45: 170: 15.14
+	Hs
		463293 ANDR_HUMAN (1-920): 0: 966: 100.00		LYN_HUMAN (404-594): 1.25e-43: 164: 20.69
+	Hs
		520073 ANDR_HUMAN (1-920): 0: 966: 100.00		SHB_HUMAN (363-590): 1e-42: 162: 22.36
+	Hs
		520202 ANDR_HUMAN (1-920): 0: 966: 100.00		SH2D3_HUMAN (371-592): 3.64e-41: 161: 19.16
+	Hs
		456086 ANDR_HUMAN (1-920): 0: 966: 100.00		FES_HUMAN (431-594): 4.94e-36: 146: 22.56
+	Hs
		519921 ANDR_HUMAN (1-920): 0: 966: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		395548 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		SHC1_HUMAN (3-593): 6.56e-176: 512: 47.06
+	Hs
		395400 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		SRC_HUMAN (361-594): 9.01e-49: 179: 17.79
+	Hs
		395341 ESR1_HUMAN (378-904): 7.63e-136: 420: 22.20		YES_HUMAN (355-594): 4.7e-48: 177: 17.31
+	Rn
		439610 ESR1_RAT (378-904): 2.2e-130: 406: 20.94		SRC_RAT (361-594): 3.22e-48: 178: 17.39
+	Mm
		431322 ESR1_MOUSE (378-904): 2.51e-129: 403: 21.30		SRC_MOUSE (361-594): 3.66e-49: 180: 17.46
+	Hs
		403735 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		FYN_HUMAN (438-585): 1.21e-43: 165: 20.76