HitPredict - High confidence protein-protein interactions

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: MCL1 (Q07820)
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
Gene: MCL1

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	7937747
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bcl-2~Bcl-2, BH4~Bcl-2
Common GO terms	GO:0001836 - release of cytochrome c from mitochondria GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane and 14 others more... GO:0005829 - cytosol GO:0006974 - DNA damage response GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0010507 - negative regulation of autophagy GO:0015267 - channel activity GO:0016020 - membrane GO:0034097 - response to cytokine GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0046982 - protein heterodimerization activity GO:0051434 - BH3 domain binding GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand GO:2000811 - negative regulation of anoikis GO:2001240 - negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	239
Hs

1	350

Service provided by Combinatics, Japan

Last updated: 11Aug2025