Interactor 1: BAK (O08734)
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)
Gene: Bak1
Interactor 2: MCL1 (P97287)
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1)
Gene: MCL1
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.47 | 1.00 | 0.692 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 18589438 |
| Identification Methods | isothermal titration calorimetry, nuclear magnetic resonance |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Bcl-2~Bcl-2 |
| Common GO terms | GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043065 - positive regulation of apoptotic process GO:0046982 - protein heterodimerization activity and 1 others more... |
| Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
