HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SEPT6 (Q14141)
Septin-6
Gene: SEPTIN6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0015630 - microtubule cytoskeleton
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 434
+	Hs
		530147 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Mm
		530939 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		SEPT6_MOUSE (1-434): 0: 606: 96.08
+	Hs
		530448 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEP11_HUMAN (3-400): 0: 548: 83.92
+	Hs
		94483 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		D6RGI3_HUMAN (3-400): 0: 547: 83.92
+	Hs
		804 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		A0A087X142_HUMAN (1-427): 0: 543: 74.36
+	Hs
		529872 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT7_HUMAN (2-425): 0: 529: 38.94
+	Mm
		530872 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		SEPT8_MOUSE (1-427): 0: 566: 76.46
+	Rn
		620111 TAU_RAT (1-758): 3.21e-76: 263: 72.11		SEPT7_RAT (2-425): 0: 537: 38.80
+	Rn
		98802 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		SEPT7_RAT (2-425): 0: 537: 38.80
+	Hs
		210482 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT4_HUMAN (22-363): 8.1e-168: 481: 38.89
+	Hs
		530275 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT5_HUMAN (22-363): 8.04e-164: 467: 40.06
+	Hs
		529818 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT2_HUMAN (16-348): 1.31e-159: 456: 39.77
+	Hs
		530526 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT9_HUMAN (9-323): 2.66e-152: 445: 39.94
+	Hs
		530520 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT3_HUMAN (7-307): 1.9e-152: 437: 40.45
+	Hs
		161477 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		SEPT7_HUMAN (2-425): 0: 529: 38.94