HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SEPT5 (Q99719)
Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1)
Gene: SEPTIN5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0015630 - microtubule cytoskeleton
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 369
+	Hs
		210482 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT4_HUMAN (14-368): 0: 523: 76.92
+	Hs
		529872 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT7_HUMAN (2-368): 5.47e-173: 490: 48.83
+	Hs
		529818 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT2_HUMAN (7-361): 6.95e-171: 482: 57.75
+	Hs
		530147 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT8_HUMAN (1-356): 4.59e-164: 469: 39.61
+	Hs
		530448 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEP11_HUMAN (10-358): 6.37e-164: 467: 38.98
+	Hs
		94483 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		D6RGI3_HUMAN (10-358): 1.5e-163: 465: 38.98
+	Hs
		530526 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT9_HUMAN (8-329): 1.2e-158: 459: 45.20
+	Hs
		529777 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT6_HUMAN (17-362): 1.09e-160: 458: 40.46
+	Rn
		620111 TAU_RAT (1-758): 3.21e-76: 263: 72.11		SEPT7_RAT (2-368): 2.06e-173: 491: 49.09
+	Rn
		98802 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		SEPT7_RAT (2-368): 2.06e-173: 491: 49.09
+	Hs
		530520 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SEPT3_HUMAN (8-333): 1.11e-158: 451: 45.62
+	Hs
		804 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		A0A087X142_HUMAN (12-355): 1.75e-153: 440: 39.54
+	Mm
		530872 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		SEPT8_MOUSE (1-356): 1.64e-161: 460: 39.34
+	Mm
		530939 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		SEPT6_MOUSE (13-362): 3.4e-160: 457: 39.72
+	Hs
		161477 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		SEPT7_HUMAN (2-368): 5.47e-173: 490: 48.83