HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ZFHX2 (Q9C0A1)
Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2)
Gene: ZFHX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2572
+	Hs
		895783 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		LHX2_HUMAN (1769-1991): 1.26e-37: 149: 21.54
+	Hs
		161436 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		LHX2_HUMAN (1769-1991): 1.26e-37: 149: 21.54
+	Hs
		895758 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		LHX2_HUMAN (1769-1991): 1.26e-37: 149: 21.54
+	Hs
		1401453 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		LHX6_HUMAN (1830-1944): 2.9e-36: 144: 34.78
+	Hs
		1288841 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		ZFHX4_HUMAN (1265-2244): 4.71e-31: 137: 13.17
+	Hs
		1401424 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		LHX3_HUMAN (1584-1828): 1.62e-20: 98.5: 21.91
+	Hs
		1379935 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		LHX4_HUMAN (1585-1658): 3.45e-20: 97.4: 33.78
+	Hs
		161521 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		LHX3_HUMAN (1584-1828): 1.62e-20: 98.5: 21.91
+	Hs
		1338282 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		LHX3_HUMAN (1584-1828): 1.62e-20: 98.5: 21.91
+	Mm
		1455913 PCLO_MOUSE (31-654): 3.4e-09: 62.7: 10.40		PCLO_MOUSE (1689-2559): 6.3e-19: 97.4: 12.22
+	Hs
		161501 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		LHX4_HUMAN (1585-1658): 3.45e-20: 97.4: 33.78
+	Hs
		1338264 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		LHX4_HUMAN (1585-1658): 3.45e-20: 97.4: 33.78
+	Mm
		312712 F186A_MOUSE (179-754): 1.25e-15: 83.5: 7.55		LMX1B_MOUSE (2022-2122): 5.03e-12: 72.6: 34.65
+	Hs
		161433 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		LHX1_HUMAN (1553-1809): 6.26e-17: 87.7: 18.02
+	Hs
		877533 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		LHX1_HUMAN (1553-1809): 6.26e-17: 87.7: 18.02
+	Hs
		161479 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		LHX8_HUMAN (1592-1652): 1.35e-13: 76.9: 37.71
+	Hs
		253024 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		LMX1B_HUMAN (2022-2122): 5.6e-12: 72.6: 34.65
+	Hs
		1155986 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		ZFHX3_HUMAN (1923-2471): 1.93e-09: 65.9: 12.79