HitPredict

Interactor 1: SYDC (P14868)
Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)
Gene: DARS1

Interactor 2: SYLC (Q9P2J5)
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)
Gene: LARS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 27684187, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017101 - aminoacyl-tRNA synthetase multienzyme complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 1176
+	Hs
		1065588 SYK_HUMAN (14-495): 2.23e-154: 454: 18.88		SYLC_HUMAN (1-1176): 0: 1211: 100.00
+	Sc
		389056 SYDC_YEAST (9-501): 0: 530: 56.46		SYLC_YEAST (5-1063): 0: 795: 44.18
+	Hs
		541324 SYDC_HUMAN (1-501): 0: 617: 100.00		SYIC_HUMAN (5-1136): 0: 692: 15.44
+	Sc
		643666 SYNC_YEAST (5-501): 6.15e-165: 479: 25.44		SYLC_YEAST (5-1063): 0: 795: 44.18
+	Sc
		546147 SYKC_YEAST (12-493): 1.1e-140: 418: 18.88		SYLC_YEAST (5-1063): 0: 795: 44.18
+	Dm
		1178626 Q7K0E6_DROME (19-501): 0: 562: 68.66		Q8MSW0_DROME (7-1129): 0: 646: 15.02
+	Sc
		389036 SYDC_YEAST (9-501): 0: 530: 56.46		SYV_YEAST (9-998): 0: 638: 14.78
+	Hs
		783040 SYK_HUMAN (14-495): 2.23e-154: 454: 18.88		SYIC_HUMAN (5-1136): 0: 692: 15.44
+	Sc
		430774 SYNC_YEAST (5-501): 6.15e-165: 479: 25.44		SYV_YEAST (9-998): 0: 638: 14.78
+	Sc
		450305 SYNC_YEAST (5-501): 6.15e-165: 479: 25.44		SYIC_YEAST (11-1151): 0: 624: 13.58
+	Sc
		430745 SYKC_YEAST (12-493): 1.1e-140: 418: 18.88		SYV_YEAST (9-998): 0: 638: 14.78
+	Ec
		343736 SYK2_ECOLI (9-496): 2.17e-153: 448: 20.70		SYI_ECOLI (5-983): 0: 603: 13.97