HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: NOSTN (Q8IVI9)
Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer)
Gene: NOSTRIN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	22751148
Identification Methods	pull down, two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 506
+	Mm
		591450 FGFR1_MOUSE (1-822): 0: 856: 98.42		NOSTN_MOUSE (1-506): 6.58e-79: 257: 82.61
+	Hs
		541755 FGFR1_HUMAN (1-822): 0: 858: 100.00		PACN2_HUMAN (6-496): 6.47e-61: 209: 15.81
+	Hs
		541453 FGFR1_HUMAN (1-822): 0: 858: 100.00		FCHO2_HUMAN (11-432): 7.77e-49: 181: 14.59
+	Hs
		541646 FGFR1_HUMAN (1-822): 0: 858: 100.00		FNBP1_HUMAN (14-380): 4.13e-46: 171: 16.31
+	Hs
		541691 FGFR1_HUMAN (1-822): 0: 858: 100.00		PPIP2_HUMAN (6-318): 6.06e-44: 160: 18.21
+	Hs
		541659 FGFR1_HUMAN (1-822): 0: 858: 100.00		SH3G1_HUMAN (132-500): 2.09e-42: 156: 18.35
+	Hs
		541723 FGFR1_HUMAN (1-822): 0: 858: 100.00		ITSN2_HUMAN (342-499): 3.87e-15: 80.7: 15.72
+	Hs
		541629 FGFR1_HUMAN (1-822): 0: 858: 100.00		SH3K1_HUMAN (445-506): 1.13e-14: 78.8: 35.94
+	Hs
		541538 FGFR1_HUMAN (1-822): 0: 858: 100.00		FBP1L_HUMAN (291-492): 2.22e-10: 64.9: 16.18
+	Hs
		269504 FGFR1_HUMAN (1-822): 0: 858: 100.00		SRGP2_HUMAN (31-506): 1.08e-09: 63.3: 12.18
+	Hs
		541509 FGFR1_HUMAN (1-822): 0: 858: 100.00		ITSN1_HUMAN (424-504): 2.07e-09: 62.6: 25.58
+	Hs
		641273 FGFR2_HUMAN (1-812): 0: 794: 71.50		ITSN2_HUMAN (342-499): 3.87e-15: 80.7: 15.72
+	Hs
		648741 FGFR4_HUMAN (31-813): 0: 660: 55.33		PACN2_HUMAN (6-496): 6.47e-61: 209: 15.81
+	Hs
		648495 FGFR4_HUMAN (31-813): 0: 660: 55.33		FCHO2_HUMAN (11-432): 7.77e-49: 181: 14.59
+	Hs
		648679 FGFR4_HUMAN (31-813): 0: 660: 55.33		PPIP2_HUMAN (6-318): 6.06e-44: 160: 18.21
+	Hs
		319199 FGFR3_HUMAN (6-821): 0: 727: 61.22		FCSD2_HUMAN (28-504): 2.98e-13: 74.5: 12.63
+	Hs
		648704 FGFR4_HUMAN (31-813): 0: 660: 55.33		ITSN2_HUMAN (342-499): 3.87e-15: 80.7: 15.72
+	Hs
		648547 FGFR4_HUMAN (31-813): 0: 660: 55.33		FBP1L_HUMAN (291-492): 2.22e-10: 64.9: 16.18
+	Hs
		648527 FGFR4_HUMAN (31-813): 0: 660: 55.33		ITSN1_HUMAN (424-504): 2.07e-09: 62.6: 25.58
+	Hs
		269516 EPHB2_HUMAN (4-819): 0: 637: 18.07		SRGP2_HUMAN (31-506): 1.08e-09: 63.3: 12.18