HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: UFD4 (P33202)
Ubiquitin fusion degradation protein 4 (UB fusion protein 4) (EC 2.3.2.-) (HECT-type E3 ubiquitin transferase UFD4) (EC 2.3.2.26)
Gene: UFD4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	19536198
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 1483
+	Hs
		125101 HS90B_HUMAN (5-705): 0: 1022: 61.15		WWP2_HUMAN (610-1480): 0: 722: 16.39
+	Hs
		125097 HS90A_HUMAN (4-705): 0: 1013: 60.67		WWP2_HUMAN (610-1480): 0: 722: 16.39
+	Hs
		438516 HS90B_HUMAN (5-705): 0: 1022: 61.15		WWP1_HUMAN (640-1480): 0: 660: 16.18
+	Hs
		432252 HS90A_HUMAN (4-705): 0: 1013: 60.67		WWP1_HUMAN (640-1480): 0: 660: 16.18
+	Hs
		438333 HS90B_HUMAN (5-705): 0: 1022: 61.15		HERC6_HUMAN (709-1479): 1.13e-161: 517: 17.34
+	Sc
		544310 HSC82_YEAST (1-705): 0: 977: 100.00		TOM1_YEAST (595-1483): 1.37e-167: 562: 16.87
+	Sc
		366793 HSP82_YEAST (1-705): 0: 968: 95.63		TOM1_YEAST (595-1483): 1.37e-167: 562: 16.87
+	Hs
		432034 HS90A_HUMAN (4-705): 0: 1013: 60.67		HERC6_HUMAN (709-1479): 1.13e-161: 517: 17.34
+	Sc
		543785 HSC82_YEAST (1-705): 0: 977: 100.00		RSP5_YEAST (774-1480): 1.01e-176: 550: 15.57
+	Sc
		366333 HSP82_YEAST (1-705): 0: 968: 95.63		RSP5_YEAST (774-1480): 1.01e-176: 550: 15.57
+	Hs
		538146 ENPL_HUMAN (3-680): 0: 893: 47.10		NEDD4_HUMAN (801-1482): 3.61e-180: 575: 17.77
+	Hs
		438617 HS90B_HUMAN (5-705): 0: 1022: 61.15		HECD1_HUMAN (1277-1475): 3.61e-27: 123: 35.44
+	Hs
		438245 HS90B_HUMAN (5-705): 0: 1022: 61.15		HERC4_HUMAN (1260-1482): 2.58e-22: 106: 31.44
+	Hs
		438095 HS90B_HUMAN (5-705): 0: 1022: 61.15		UBE3A_HUMAN (1204-1482): 2.39e-21: 103: 29.17
+	Hs
		438309 HS90B_HUMAN (5-705): 0: 1022: 61.15		HUWE1_HUMAN (1191-1483): 1.44e-20: 101: 31.51
+	Hs
		431935 HS90A_HUMAN (4-705): 0: 1013: 60.67		HERC4_HUMAN (1260-1482): 2.58e-22: 106: 31.44
+	Hs
		432005 HS90A_HUMAN (4-705): 0: 1013: 60.67		HUWE1_HUMAN (1191-1483): 1.44e-20: 101: 31.51
+	Hs
		538246 ENPL_HUMAN (3-680): 0: 893: 47.10		UBE3C_HUMAN (1185-1478): 1.15e-26: 120: 29.43
+	Hs
		538295 ENPL_HUMAN (3-680): 0: 893: 47.10		HUWE1_HUMAN (1191-1483): 1.44e-20: 101: 31.51
+	Zm
		17433 A0A1D6GWE1_MAIZE (2-674): 0: 548: 48.36		A0A1D6MU59_MAIZE (1201-1480): 3.62e-21: 103: 29.45