HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: SP16H (Q9Y5B9)
FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)
Gene: SUPT16H

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.953

Property	Details
Experiments	24981860, 28514442, 28242625, 33961781, 16522924, 18406329
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~Rtt106, Histone_H2A_C~Rtt106
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 1047
+	Mm
		650195 H2AX_MOUSE (1-143): 1.9e-73: 217: 97.20		SP16H_MOUSE (1-1047): 0: 1332: 98.66
+	Hs
		1151400 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		1185216 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		391984 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		470626 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		1087145 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		1312248 H2AJ_HUMAN (1-125): 5.62e-65: 195: 93.60		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		261051 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Sc
		392084 H2A1_YEAST (16-142): 1.37e-53: 166: 75.59		SPT16_YEAST (3-1008): 0: 938: 33.49
+	Sc
		392353 H2A2_YEAST (16-124): 4.61e-53: 165: 82.57		SPT16_YEAST (3-1008): 0: 938: 33.49