HitPredict

Interactor 1: LYAM3 (P16109)
P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
Gene: SELP

Interactor 2: SELPL (Q14242)
P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)
Gene: SELPLG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	10713099, 19118202, 11081633, 26627825
Identification Methods	affinity chromatography technology, surface plasmon resonance, solid phase assay, x-ray crystallography, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0050901 - leukocyte tethering or rolling
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 830 Hs			1 412
+	Mm
		961582 LYAM2_MOUSE (419-829): 9.76e-41: 161: 29.71		SELPL_MOUSE (1-412): 1.94e-45: 163: 44.06
+	Hs
		530378 CSPG2_HUMAN (297-567): 2.32e-11: 70.1: 14.15		SELPL_HUMAN (1-412): 2.62e-63: 211: 100.00
+	Hs
		416131 CO2_HUMAN (633-781): 1.22e-15: 83.4: 20.51		MUC1_HUMAN (1-326): 8.4e-16: 81.6: 14.02
+	Hs
		257648 FRAS1_HUMAN (98-429): 4.16e-11: 69.4: 11.71		ANR17_HUMAN (7-334): 7.19e-20: 94.3: 10.84
+	Dm
		246710 TENM_DROME (84-412): 7.11e-14: 78.2: 11.27		RPB1_DROME (13-327): 1.06e-11: 68.9: 9.09
+	Dm
		247257 TENM_DROME (84-412): 7.11e-14: 78.2: 11.27		Q9VYN1_DROME (21-318): 8.16e-09: 60: 12.67
+	Hs
		1166446 SE6L2_HUMAN (139-334): 2.03e-09: 63.6: 20.30		TMPSD_HUMAN (134-283): 2.91e-09: 60.8: 15.13