HitPredict - High confidence protein-protein interactions

Interactor 1: KAP2 (P13861)
cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene: PRKAR2A

Interactor 2: KAP2 (P13861)
cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene: PRKAR2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	31182485, 23071553
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	cNMP_binding~cNMP_binding, RIIa~RIIa
Common GO terms	GO:0004862 - cAMP-dependent protein kinase inhibitor activity GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005886 - plasma membrane and 16 others more... GO:0005925 - focal adhesion GO:0005952 - cAMP-dependent protein kinase complex GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0008603 - cAMP-dependent protein kinase regulator activity GO:0016020 - membrane GO:0019904 - protein domain specific binding GO:0030552 - cAMP binding GO:0031588 - nucleotide-activated protein kinase complex GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0034236 - protein kinase A catalytic subunit binding GO:0035556 - intracellular signal transduction GO:0044853 - plasma membrane raft GO:0070062 - extracellular exosome GO:0097546 - ciliary base GO:0141162 - negative regulation of cAMP/PKA signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	404
Hs

1	404

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Last updated: 11Aug2025