HitPredict

Interactor 1: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Interactor 2: NEST (P48681)
Nestin
Gene: NES

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	26496610, 21185309, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1019 Hs			1 1621
+	Hs
		474445 IDE_HUMAN (1-1019): 0: 1084: 100.00		VIME_HUMAN (8-343): 3.06e-118: 382: 28.32
+	Hs
		570347 IDE_HUMAN (1-1019): 0: 1084: 100.00		GFAP_HUMAN (8-316): 8.24e-22: 102: 30.35
+	Hs
		451116 IDE_HUMAN (1-1019): 0: 1084: 100.00		NFL_HUMAN (7-323): 1.31e-18: 93.6: 27.95
+	Hs
		575138 IDE_HUMAN (1-1019): 0: 1084: 100.00		AINX_HUMAN (8-317): 2.3e-17: 89.4: 27.59
+	Hs
		451324 IDE_HUMAN (1-1019): 0: 1084: 100.00		NFM_HUMAN (8-333): 4.78e-14: 79.7: 26.21
+	Hs
		1127810 PREP_HUMAN (91-965): 1.14e-133: 431: 13.57		KRT81_HUMAN (6-313): 7.09e-64: 228: 21.34
+	Hs
		227232 PREP_HUMAN (91-965): 1.14e-133: 431: 13.57		KRT86_HUMAN (6-313): 8.95e-63: 224: 21.34
+	Hs
		227189 MPPB_HUMAN (49-493): 2.23e-113: 360: 16.81		KRT86_HUMAN (6-313): 8.95e-63: 224: 21.34
+	Hs
		281848 MPPB_HUMAN (49-493): 2.23e-113: 360: 16.81		K2C75_HUMAN (6-319): 2.23e-59: 217: 21.43
+	Hs
		227215 MPPA_HUMAN (6-482): 9.41e-106: 341: 14.54		KRT86_HUMAN (6-313): 8.95e-63: 224: 21.34
+	Hs
		281903 MPPB_HUMAN (49-493): 2.23e-113: 360: 16.81		MYH9_HUMAN (758-1511): 2.36e-26: 120: 9.72
+	Hs
		281877 MPPB_HUMAN (49-493): 2.23e-113: 360: 16.81		DESM_HUMAN (8-316): 2.11e-14: 79.7: 25.47
+	Hs
		606107 MPPA_HUMAN (6-482): 9.41e-106: 341: 14.54		DESM_HUMAN (8-316): 2.11e-14: 79.7: 25.47