HitPredict

Interactor 1: FGFR1 (P16092)
Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: FRS3 (Q91WJ0)
Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta)
Gene: FRS3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17901128, 16887332
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Mm			1 492
+	Hs
		220219 FGFR1_HUMAN (1-822): 0: 844: 98.42		FRS3_HUMAN (1-492): 0: 647: 85.08
+	Hs
		541611 FGFR1_HUMAN (1-822): 0: 844: 98.42		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Mm
		591453 FGFR1_MOUSE (1-822): 0: 847: 100.00		FRS2_MOUSE (1-492): 0: 571: 46.07
+	Hs
		641220 FGFR2_HUMAN (1-811): 0: 786: 71.34		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		650319 FGFR3_HUMAN (1-821): 0: 721: 61.45		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		648604 FGFR4_HUMAN (30-807): 0: 648: 56.78		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		932105 EPHA4_HUMAN (3-821): 0: 636: 19.33		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		710393 EPHA2_HUMAN (3-820): 0: 592: 18.58		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		1157008 NTRK3_HUMAN (111-762): 2.44e-170: 515: 23.30		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		1159520 NTRK2_HUMAN (58-762): 4.71e-161: 490: 22.52		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		412315 NTRK1_HUMAN (122-762): 2.97e-154: 472: 26.10		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		464018 RET_HUMAN (228-820): 9.39e-132: 422: 35.34		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Mm
		1179066 NTRK3_MOUSE (111-762): 1.55e-174: 525: 24.08		DOK6_MOUSE (34-184): 1.04e-28: 117: 26.83
+	Hs
		1156976 NTRK3_HUMAN (111-762): 2.44e-170: 515: 23.30		DOK6_HUMAN (34-151): 2.05e-28: 116: 27.05
+	Hs
		464042 RET_HUMAN (228-820): 9.39e-132: 422: 35.34		DOK1_HUMAN (19-313): 3.73e-51: 182: 20.88
+	Hs
		249712 RET_HUMAN (228-820): 9.39e-132: 422: 35.34		DOK2_HUMAN (20-290): 5.39e-32: 128: 21.31
+	Hs
		463988 RET_HUMAN (228-820): 9.39e-132: 422: 35.34		DOK6_HUMAN (34-151): 2.05e-28: 116: 27.05
+	Hs
		464017 RET_HUMAN (228-820): 9.39e-132: 422: 35.34		DOK4_HUMAN (34-143): 2e-27: 114: 21.93
+	Hs
		464068 RET_HUMAN (228-820): 9.39e-132: 422: 35.34		DOK5_HUMAN (34-139): 4.44e-27: 112: 24.58
+	Mm
		483861 CSF1R_MOUSE (464-769): 9.35e-78: 273: 42.11		DOK1_MOUSE (19-247): 1.51e-61: 210: 24.90