Protein: FRS3
Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FGFR-signaling adaptor SNT2) (Suc1-associated neurotrophic factor target 2) (SNT-2)

Gene: FRS3
Organism: Homo sapiens
Interactions: 122
UniProt ID: O43559

Gene Ontology (top 5):
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104 - fibroblast growth factor receptor binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

220211

FRS3
Fibroblast growth factor receptor substrate 3

4

9

High-throughput

0.901

High

220242

GRB14
Growth factor receptor-bound protein 14

2

20

High-throughput

0.743

High

220310

SH2B1
SH2B adapter protein 1

2

20

High-throughput

0.743

High

220309

PDLI7
PDZ and LIM domain protein 7

2

1

High-throughput

0.700

High

220246

TRIP6
Thyroid receptor-interacting protein 6

3

1

High-throughput

0.675

High

220262

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.633

High

220217

HCK
Tyrosine-protein kinase HCK

2

20

High-throughput

0.628

High

220239

TLE5
TLE family member 5

3

1

High-throughput

0.616

High

220214

STK16
Serine/threonine-protein kinase 16

2

4

High-throughput

0.606

High

220234

ID2
DNA-binding protein inhibitor ID-2

2

1

High-throughput

0.606

High

220235

ID3
DNA-binding protein inhibitor ID-3

2

1

High-throughput

0.606

High

220240

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

220276

CTSR1
Cation channel sperm-associated protein 1

2

1

High-throughput

0.606

High

220295

TRAF4
TNF receptor-associated factor 4

2

2

High-throughput

0.606

High

220226

MATK
Megakaryocyte-associated tyrosine-protein kinase

2

20

High-throughput

0.594

High

220229

NUMB
Protein numb homolog

2

3

High-throughput

0.594

High

165159

TSN4
Tetraspanin-4

2

0

High-throughput

0.580

High

220227

CCN3
CCN family member 3

2

0

High-throughput

0.580

High

220248

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.580

High

220253

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

220255

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.580

High

220256

NADE
Glutamine-dependent NAD(+) synthetase

2

0

High-throughput

0.580

High

220258

PLB1
Phospholipase B1, membrane-associated

2

0

High-throughput

0.580

High

220264

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.580

High

220270

STH
Saitohin

2

0

High-throughput

0.580

High

220272

LRC18
Leucine-rich repeat-containing protein 18

2

0

High-throughput

0.580

High

220275

SLAI1
SLAIN motif-containing protein 1

2

0

High-throughput

0.580

High

220283

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.580

High

220291

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

2

0

High-throughput

0.580

High

220300

KTBL1
KATNB1-like protein 1

2

0

High-throughput

0.580

High

220301

GO45
Golgin-45

2

0

High-throughput

0.580

High

220313

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

220316

IKZF3
Zinc finger protein Aiolos

2

0

High-throughput

0.580

High

220319

CSN3
COP9 signalosome complex subunit 3

2

0

High-throughput

0.580

High

220320

PLLP
Plasmolipin

2

0

High-throughput

0.580

High

220322

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.580

High

220286

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.579

High

155980

SOCS6
Suppressor of cytokine signaling 6

2

20

High-throughput

0.576

High

220305

TENS1
Tensin-1

2

1

High-throughput

0.576

High

220285

SOCS4
Suppressor of cytokine signaling 4

2

20

High-throughput

0.573

High

220212

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.573

High

220230

VASP
Vasodilator-stimulated phosphoprotein

2

0

High-throughput

0.569

High

220215

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.553

High

220225

HXD12
Homeobox protein Hox-D12

2

2

High-throughput

0.553

High

220228

HXA1
Homeobox protein Hox-A1

2

1

High-throughput

0.553

High

220231

KR108
Keratin-associated protein 10-8

2

1

High-throughput

0.553

High

220238

KRA11
Keratin-associated protein 1-1

2

1

High-throughput

0.553

High

220243

KT33B
Keratin, type I cuticular Ha3-II

2

3

High-throughput

0.553

High

220245

K1H1
Keratin, type I cuticular Ha1

2

3

High-throughput

0.553

High

220247

ZN124
Zinc finger protein 124

2

1

High-throughput

0.553

High

220249

ANR55
Ankyrin repeat domain-containing protein 55

2

1

High-throughput

0.553

High

220278

ZN417
Zinc finger protein 417

2

1

High-throughput

0.553

High

220288

KRT35
Keratin, type I cuticular Ha5

2

3

High-throughput

0.553

High

220298

KRA32
Keratin-associated protein 3-2

2

1

High-throughput

0.553

High

220299

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.553

High

220303

ZN552
Zinc finger protein 552

2

1

High-throughput

0.553

High

220311

ZN446
Zinc finger protein 446

2

1

High-throughput

0.553

High

180451

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.549

High

220297

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.541

High

220293

SPAG8
Sperm-associated antigen 8

1

1

High-throughput

0.515

High

220315

RIM3A
RIMS-binding protein 3A

1

2

High-throughput

0.515

High

220318

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.493

High

66392

RIM3C
RIMS-binding protein 3C

1

2

High-throughput

0.481

High

220219

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.481

High

220222

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.481

High

220287

TSC1
Hamartin

1

2

High-throughput

0.481

High

220216

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.479

High

220223

CBL
E3 ubiquitin-protein ligase CBL

1

3

Small-scale

0.479

High

220241

BMPR2
Bone morphogenetic protein receptor type-2

1

2

Small-scale

0.479

High

220290

SH3K1
SH3 domain-containing kinase-binding protein 1

1

17

Small-scale

0.479

High

220321

CD2AP
CD2-associated protein

1

16

Small-scale

0.479

High

220218

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

220267

Q86WV8
TSC complex subunit 1

1

2

High-throughput

0.470

High

446

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.460

High

220213

GRIN2
G protein-regulated inducer of neurite outgrowth 2

1

0

High-throughput

0.460

High

220237

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

6

Small-scale

0.457

High

220232

YPEL3
Protein yippee-like 3

1

1

High-throughput

0.439

High

220244

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.438

High

220252

Q59E92
RNA helicase

1

1

High-throughput

0.417

High

220221

GATA1
Erythroid transcription factor

3

0

High-throughput

0.352

High

220268

RFX6
DNA-binding protein RFX6

3

0

High-throughput

0.352

High

61014

DCD2B
Doublecortin domain-containing protein 2B

2

0

High-throughput

0.316

High

70041

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

71092

VGLL3
Transcription cofactor vestigial-like protein 3

2

0

High-throughput

0.316

High

220224

CO8A1
Collagen alpha-1(VIII) chain

2

0

High-throughput

0.316

High

220233

K22O
Keratin, type II cytoskeletal 2 oral

2

0

High-throughput

0.316

High

220236

CREB5
Cyclic AMP-responsive element-binding protein 5

2

0

High-throughput

0.316

High

220250

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

220251

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

220254

MIIP
Migration and invasion-inhibitory protein

2

0

High-throughput

0.316

High

220257

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

2

0

High-throughput

0.316

High

220259

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

220261

K0408
Uncharacterized protein KIAA0408

2

0

High-throughput

0.316

High

220263

ZN438
Zinc finger protein 438

2

0

High-throughput

0.316

High

220265

SPT12
Spermatogenesis-associated protein 12

2

0

High-throughput

0.316

High

220266

ZSC30
Zinc finger and SCAN domain-containing protein 30

2

0

High-throughput

0.316

High

220269

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

220271

BWR1B
Uncharacterized protein SLC67A1-AS

2

0

High-throughput

0.316

High

220277

ZMIZ2
Zinc finger MIZ domain-containing protein 2

2

0

High-throughput

0.316

High

220279

KC5S1
Uncharacterized protein KCNJ5-AS1

2

0

High-throughput

0.316

High

220280

TCP1L
T-complex protein 10A homolog 1

2

0

High-throughput

0.316

High

220282

POF1B
Protein POF1B

2

0

High-throughput

0.316

High

220284

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

0

High-throughput

0.316

High

220289

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

0

High-throughput

0.316

High

220292

TGM7
Protein-glutamine gamma-glutamyltransferase Z

2

0

High-throughput

0.316

High

220294

WDR83
WD repeat domain-containing protein 83

2

0

High-throughput

0.316

High

220296

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.316

High

220302

CFA68
Cilia- and flagella-associated protein 68

2

0

High-throughput

0.316

High

220304

UNKL
Putative E3 ubiquitin-protein ligase UNKL

2

0

High-throughput

0.316

High

220306

ESM1
Endothelial cell-specific molecule 1

2

0

High-throughput

0.316

High

220307

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

0

High-throughput

0.316

High

220308

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

0

High-throughput

0.316

High

220312

APC11
Anaphase-promoting complex subunit 11

2

0

High-throughput

0.316

High

220314

ZNF69
Zinc finger protein 69

2

0

High-throughput

0.316

High

220317

ISY1
Pre-mRNA-splicing factor ISY1 homolog

2

0

High-throughput

0.316

High

220220

ITF2
Transcription factor 4

1

0

High-throughput

0.299

High

220260

ATL4
ADAMTS-like protein 4

1

0

High-throughput

0.299

High

220274

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.299

High

3656

DP2NB
DPEP2 neighbor protein

1

0

High-throughput

0.268

Low

220281

ZFP90
Zinc finger protein 90 homolog

1

0

High-throughput

0.268

Low

220273

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025