Protein: DOK4
Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)

Gene: DOK4
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q8TEW6

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0007399 - nervous system development
GO:0043410 - positive regulation of MAPK cascade

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1272285

DOK3
Docking protein 3

2

11

High-throughput

0.819

High

585809

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

3

0

High-throughput

0.816

High

1051027

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.767

High

1353323

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

3

0

High-throughput

0.720

High

1353341

STK24
Serine/threonine-protein kinase 24

1

2

High-throughput

0.691

High

1353336

RCOR3
REST corepressor 3

4

4

High-throughput

0.691

High

230080

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

3

1

High-throughput

0.667

High

854445

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

3

1

High-throughput

0.667

High

1290276

KBTB6
Kelch repeat and BTB domain-containing protein 6

3

5

High-throughput

0.667

High

1353316

KBTB7
Kelch repeat and BTB domain-containing protein 7

3

4

High-throughput

0.667

High

1353317

KPBB
Phosphorylase b kinase regulatory subunit beta

3

1

High-throughput

0.667

High

1353321

SAHH3
Adenosylhomocysteinase 3

3

1

High-throughput

0.667

High

363610

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

410959

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

1270916

RHOU
Rho-related GTP-binding protein RhoU

1

19

High-throughput

0.647

High

1091435

ANK3
Ankyrin-3

3

0

High-throughput

0.638

High

1353333

CWC22
Pre-mRNA-splicing factor CWC22 homolog

3

0

High-throughput

0.638

High

1353334

HM20A
High mobility group protein 20A

4

4

High-throughput

0.630

High

1353337

RCOR1
REST corepressor 1

4

4

High-throughput

0.630

High

464017

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.618

High

1322538

MIER1
Mesoderm induction early response protein 1

2

4

High-throughput

0.611

High

1353330

CCM2
Cerebral cavernous malformations 2 protein

2

0

High-throughput

0.607

High

1081416

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1353327

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.606

High

1353339

KLH20
Kelch-like protein 20

2

2

High-throughput

0.601

High

913149

STAT2
Signal transducer and activator of transcription 2

2

2

High-throughput

0.594

High

246808

KDM1A
Lysine-specific histone demethylase 1A

3

2

High-throughput

0.593

High

1056631

PAX8
Paired box protein Pax-8

2

0

High-throughput

0.580

High

1123054

FHL2
Four and a half LIM domains protein 2

2

1

High-throughput

0.574

High

702361

ELK4
ETS domain-containing protein Elk-4

1

2

Small-scale

0.561

High

1325974

LIX1
Protein limb expression 1 homolog

2

0

High-throughput

0.551

High

1353326

RET7
Retinoid-binding protein 7

2

0

High-throughput

0.551

High

1353338

MARE3
Microtubule-associated protein RP/EB family member 3

2

0

High-throughput

0.551

High

1050491

UBE3A
Ubiquitin-protein ligase E3A

1

4

High-throughput

0.536

High

1324903

RHG18
Rho GTPase-activating protein 18

1

4

High-throughput

0.536

High

770892

OPRM
Mu-type opioid receptor

1

3

Small-scale

0.535

High

1347273

OLIG1
Oligodendrocyte transcription factor 1

2

1

High-throughput

0.526

High

49334

SHOT1
Shootin-1

1

0

High-throughput

0.513

High

186378

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.513

High

337376

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.513

High

479449

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

1107582

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.513

High

1353319

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1353324

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.513

High

1353318

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.493

High

1103287

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.489

High

1353315

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

1

High-throughput

0.489

High

1353320

KBP
KIF-binding protein

1

1

High-throughput

0.489

High

832387

OPRK
Kappa-type opioid receptor

1

3

Small-scale

0.479

High

347831

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

622468

ELK1
ETS domain-containing protein Elk-1

1

2

Small-scale

0.437

High

832370

OPRD
Delta-type opioid receptor

1

3

Small-scale

0.437

High

1353340

TR150
Thyroid hormone receptor-associated protein 3

1

2

High-throughput

0.437

High

256538

PRA10
PRAME family member 10

1

0

High-throughput

0.426

High

1131453

RFTN1
Raftlin

1

0

High-throughput

0.426

High

1353335

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

1

High-throughput

0.407

High

1130644

GSE1
Genetic suppressor element 1

4

0

High-throughput

0.360

High

130555

SPT5H
Transcription elongation factor SPT5

3

0

High-throughput

0.347

High

1353332

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

3

0

High-throughput

0.347

High

286485

WBP4
WW domain-binding protein 4

1

0

High-throughput

0.279

Low

993467

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.279

Low

1353322

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.279

Low

1353325

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

1353328

CMS1
Protein CMSS1

1

0

High-throughput

0.279

Low

1353329

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

0

High-throughput

0.279

Low

1353331

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.279

Low

844219

ECE1
Endothelin-converting enzyme 1

1

0

High-throughput

0.249

Low

1249623

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025