Protein: DOK2
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))

Gene: DOK2
Organism: Homo sapiens
Interactions: 115
UniProt ID: O60496

Gene Ontology (top 5):
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

249716

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

9

High-throughput

0.811

High

249756

PKHO1
Pleckstrin homology domain-containing family O member 1

2

0

High-throughput

0.770

High

249762

DOK3
Docking protein 3

2

13

High-throughput

0.767

High

249794

DP13A
DCC-interacting protein 13-alpha

2

5

High-throughput

0.767

High

249698

DOK2
Docking protein 2

2

13

High-throughput

0.754

High

249717

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.754

High

249753

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

2

5

High-throughput

0.737

High

249709

LCK
Tyrosine-protein kinase Lck

3

20

Small-scale

0.646

High

221984

NCK2
Cytoplasmic protein NCK2

2

20

High-throughput

0.628

High

159433

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

6

High-throughput

0.618

High

249773

DOK1
Docking protein 1

1

13

Small-scale

0.618

High

249769

HVCN1
Voltage-gated hydrogen channel 1

2

1

High-throughput

0.611

High

249711

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.606

High

249726

TXK
Tyrosine-protein kinase TXK

2

20

High-throughput

0.606

High

249785

LANC2
LanC-like protein 2

2

0

High-throughput

0.602

High

249704

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.595

High

249724

STAT3
Signal transducer and activator of transcription 3

2

2

High-throughput

0.594

High

249727

CRK
Adapter molecule crk

2

20

High-throughput

0.594

High

249728

CRKL
Crk-like protein

2

20

High-throughput

0.594

High

249719

EVI2A
Protein EVI2A

2

0

High-throughput

0.585

High

249786

CENPM
Centromere protein M

2

0

High-throughput

0.585

High

249749

TIE2
Angiopoietin-1 receptor

2

20

Small-scale

0.584

High

123521

MYO1C
Unconventional myosin-Ic

2

2

High-throughput

0.571

High

240030

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

4

High-throughput

0.571

High

249699

H2B1K
Histone H2B type 1-K

2

8

High-throughput

0.571

High

249702

PLPHP
Pyridoxal phosphate homeostasis protein

2

1

High-throughput

0.571

High

249708

HSPB1
Heat shock protein beta-1

2

3

High-throughput

0.571

High

249713

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

4

High-throughput

0.571

High

249715

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.571

High

249720

IF4B
Eukaryotic translation initiation factor 4B

2

4

High-throughput

0.571

High

249721

SYVC
Valine--tRNA ligase

2

1

High-throughput

0.571

High

249729

CAZA2
F-actin-capping protein subunit alpha-2

2

1

High-throughput

0.571

High

249730

CAPZB
F-actin-capping protein subunit beta

2

1

High-throughput

0.571

High

249731

CAZA1
F-actin-capping protein subunit alpha-1

2

1

High-throughput

0.571

High

249733

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.571

High

249734

H2BFS
Histone H2B type F-S

2

8

High-throughput

0.571

High

249735

H2B1D
Histone H2B type 1-D

2

8

High-throughput

0.571

High

249736

ACTB
Actin, cytoplasmic 1

2

3

High-throughput

0.571

High

249737

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

4

High-throughput

0.571

High

249741

SMD1
Small nuclear ribonucleoprotein Sm D1

2

1

High-throughput

0.571

High

249745

ACTG
Actin, cytoplasmic 2

2

3

High-throughput

0.571

High

249748

OTUD4
OTU domain-containing protein 4

2

3

High-throughput

0.571

High

249750

AKA12
A-kinase anchor protein 12

2

1

High-throughput

0.571

High

249751

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

4

High-throughput

0.571

High

249757

ACTBL
Beta-actin-like protein 2

2

3

High-throughput

0.571

High

249758

H2B2F
Histone H2B type 2-F

2

8

High-throughput

0.571

High

249768

H2B1H
Histone H2B type 1-H

2

8

High-throughput

0.571

High

249774

H2B1N
Histone H2B type 1-N

2

8

High-throughput

0.571

High

249775

H2B1M
Histone H2B type 1-M

2

8

High-throughput

0.571

High

249776

H2B1L
Histone H2B type 1-L

2

8

High-throughput

0.571

High

249778

COR1B
Coronin-1B

2

2

High-throughput

0.571

High

249789

BCLF1
Bcl-2-associated transcription factor 1

2

2

High-throughput

0.571

High

249792

LIMA1
LIM domain and actin-binding protein 1

2

4

High-throughput

0.571

High

249796

COR1C
Coronin-1C

2

1

High-throughput

0.571

High

249797

ST38L
Serine/threonine-protein kinase 38-like

2

5

High-throughput

0.571

High

249799

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

3

High-throughput

0.571

High

249802

NS1BP
Influenza virus NS1A-binding protein

2

3

High-throughput

0.571

High

249770

KBP
KIF-binding protein

2

1

High-throughput

0.555

High

179276

ARPC2
Actin-related protein 2/3 complex subunit 2

2

0

High-throughput

0.547

High

249718

FLNA
Filamin-A

2

0

High-throughput

0.547

High

249732

ICLN
Methylosome subunit pICln

2

0

High-throughput

0.547

High

249739

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.547

High

249740

RUXF
Small nuclear ribonucleoprotein F

2

0

High-throughput

0.547

High

249742

SMD2
Small nuclear ribonucleoprotein Sm D2

2

0

High-throughput

0.547

High

249744

RS21
Small ribosomal subunit protein eS21

2

0

High-throughput

0.547

High

249752

MVP
Major vault protein

2

0

High-throughput

0.547

High

249754

DREB
Drebrin

2

0

High-throughput

0.547

High

249761

EIF3M
Eukaryotic translation initiation factor 3 subunit M

2

0

High-throughput

0.547

High

249764

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

0

High-throughput

0.547

High

249772

MYCBP
c-Myc-binding protein

2

0

High-throughput

0.547

High

249777

TCF25
Ribosome quality control complex subunit TCF25

2

0

High-throughput

0.547

High

249779

RIOK1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

249784

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.547

High

249801

SPIN1
Spindlin-1

2

0

High-throughput

0.547

High

249722

MK01
Mitogen-activated protein kinase 1

1

7

High-throughput

0.536

High

249747

RBM10
RNA-binding protein 10

2

4

High-throughput

0.521

High

249798

TR150
Thyroid hormone receptor-associated protein 3

2

2

High-throughput

0.521

High

192974

CFLAR
CASP8 and FADD-like apoptosis regulator

1

3

High-throughput

0.515

High

227266

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.515

High

238978

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.515

High

249701

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

5

High-throughput

0.515

High

249703

HS74L
Heat shock 70 kDa protein 4L

1

5

High-throughput

0.515

High

249738

RAB10
Ras-related protein Rab-10

1

2

High-throughput

0.515

High

249700

PALM
Paralemmin-1

1

0

High-throughput

0.513

High

249760

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.513

High

249781

FN3K
Fructosamine-3-kinase

1

0

High-throughput

0.513

High

249795

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.513

High

249705

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.501

High

249725

CSK
Tyrosine-protein kinase CSK

1

20

Small-scale

0.501

High

249788

ASF1B
Histone chaperone ASF1B

1

0

High-throughput

0.493

High

240224

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

249710

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.479

High

249712

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.479

High

249714

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.479

High

249723

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.479

High

249767

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

8

Small-scale

0.479

High

249791

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.470

High

249707

EPO
Erythropoietin

1

0

High-throughput

0.458

High

249743

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.445

High

249706

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.437

High

249782

TM38A
Trimeric intracellular cation channel type A

3

0

High-throughput

0.347

High

249765

COQ8A
Atypical kinase COQ8A, mitochondrial

2

0

High-throughput

0.328

High

249771

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

2

0

High-throughput

0.328

High

249783

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

2

0

High-throughput

0.328

High

249763

IQCF1
IQ domain-containing protein F1

2

0

High-throughput

0.318

High

249787

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.299

High

249746

ERH
Enhancer of rudimentary homolog

2

0

High-throughput

0.298

High

249766

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.298

High

249780

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

2

0

High-throughput

0.298

High

249790

TMOD3
Tropomodulin-3

2

0

High-throughput

0.298

High

249793

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.298

High

249755

PDK4
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

249759

RSBN1
Lysine-specific demethylase 9

1

0

High-throughput

0.279

Low

249800

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025