HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: SYGP1 (Q96PV0)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: SYNGAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0014069 - postsynaptic density
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 1343
+	Hs
		433821 LYN_HUMAN (1-535): 0: 535: 54.48		DAB2P_HUMAN (97-1342): 0: 779: 46.78
+	Hs
		411884 LCK_HUMAN (40-535): 0: 551: 57.60		NGAP_HUMAN (84-1341): 0: 732: 42.62
+	Hs
		434065 LYN_HUMAN (1-535): 0: 535: 54.48		NGAP_HUMAN (84-1341): 0: 732: 42.62
+	Mm
		763401 FYN_MOUSE (1-537): 0: 642: 99.44		Q91YX7_MOUSE (184-699): 8.5e-132: 427: 24.20
+	Hs
		522768 SRC_HUMAN (1-537): 0: 598: 68.21		RASA1_HUMAN (184-715): 8.42e-129: 426: 23.32
+	Hs
		522851 SRC_HUMAN (1-537): 0: 598: 68.21		IQGA1_HUMAN (219-857): 5.95e-123: 421: 13.21
+	Hs
		433252 YES_HUMAN (1-537): 0: 591: 71.61		RASA1_HUMAN (184-715): 8.42e-129: 426: 23.32
+	Hs
		411591 LCK_HUMAN (40-535): 0: 551: 57.60		RASA1_HUMAN (184-715): 8.42e-129: 426: 23.32
+	Hs
		442830 HCK_HUMAN (1-535): 0: 548: 56.64		RASA3_HUMAN (157-681): 2.29e-131: 427: 21.64
+	Hs
		442777 HCK_HUMAN (1-535): 0: 548: 56.64		RASA1_HUMAN (184-715): 8.42e-129: 426: 23.32
+	Hs
		433762 LYN_HUMAN (1-535): 0: 535: 54.48		RASA3_HUMAN (157-681): 2.29e-131: 427: 21.64
+	Mm
		639459 LYN_MOUSE (1-535): 0: 535: 53.92		Q91YX7_MOUSE (184-699): 8.5e-132: 427: 24.20
+	Hs
		433641 LYN_HUMAN (1-535): 0: 535: 54.48		IQGA1_HUMAN (219-857): 5.95e-123: 421: 13.21
+	Hs
		433751 LYN_HUMAN (1-535): 0: 535: 54.48		IQGA2_HUMAN (216-848): 1.05e-121: 416: 14.05
+	Mm
		557352 BLK_MOUSE (40-532): 2.48e-177: 510: 58.50		Q91YX7_MOUSE (184-699): 8.5e-132: 427: 24.20
+	Mm
		93302 ABL1_MOUSE (42-537): 4.1e-167: 504: 39.56		E9PYG6_MOUSE (184-699): 2.1e-129: 427: 24.20
+	Hs
		337344 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		RASA1_HUMAN (184-715): 8.42e-129: 426: 23.32
+	Hs
		411593 LCK_HUMAN (40-535): 0: 551: 57.60		NF1_HUMAN (408-712): 3.21e-82: 301: 23.21
+	Hs
		433572 LYN_HUMAN (1-535): 0: 535: 54.48		NF1_HUMAN (408-712): 3.21e-82: 301: 23.21