HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: SHAN2 (Q9UPX8)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)
Gene: SHANK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2, Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1849
+	Hs
		699897 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		SHAN2_HUMAN (1-1849): 0: 655: 100.00
+	Hs
		988035 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		SHAN2_HUMAN (1-1849): 0: 655: 100.00
+	Hs
		594095 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		594080 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		EHMT2_HUMAN (128-402): 9.35e-71: 263: 25.36
+	Hs
		320263 SRBS2_HUMAN (64-287): 7.79e-24: 105: 18.26		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		440714 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		699844 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		987917 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		1154164 ITSN1_HUMAN (1-66): 2.26e-15: 80: 25.76		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Hs
		557453 SRC_HUMAN (5-152): 5.68e-12: 68.8: 19.74		SHAN3_HUMAN (55-1847): 5.51e-108: 385: 40.03
+	Mm
		109255 P85A_MOUSE (241-376): 7.29e-23: 102: 19.57		ANK3_MOUSE (70-737): 5.1e-86: 315: 13.48
+	Hs
		593966 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		ANK2_HUMAN (198-379): 9.82e-09: 63.2: 31.87
+	Hs
		221990 NCK2_HUMAN (1-376): 1.95e-92: 283: 68.24		PSD10_HUMAN (177-371): 2.88e-12: 70.1: 29.08
+	Hs
		987867 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		EHMT2_HUMAN (128-402): 9.35e-71: 263: 25.36
+	Hs
		699855 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		Q9H4D1_HUMAN (247-481): 2.77e-35: 148: 16.17
+	Hs
		699668 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		RIPK4_HUMAN (247-481): 9.4e-35: 146: 16.17
+	Rn
		1490155 SRC_RAT (5-201): 6.79e-15: 77.8: 17.41		SHAN1_RAT (518-1849): 2.03e-26: 121: 13.24
+	Mm
		1193728 GRB2_MOUSE (3-61): 2.57e-17: 81.8: 28.81		SHAN3_MOUSE (41-249): 7.57e-15: 82.8: 11.43
+	Mm
		431345 SRC_MOUSE (5-201): 8.43e-15: 77.8: 17.41		SHAN3_MOUSE (41-249): 7.57e-15: 82.8: 11.43
+	Hs
		987550 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		ANK2_HUMAN (198-379): 9.82e-09: 63.2: 31.87