HitPredict

Interactor 1: SPTN1 (P16546)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)
Gene: Sptan1

Interactor 2: ANK2 (Q8C8R3)
Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin)
Gene: ANK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22632975
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1, Spectrin~UPA_2, Spectrin~ZU5
Common GO terms	GO:0030018 - Z disc GO:0033010 - paranodal junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Mm			1 3898
+	Hs
		1028731 SPTB2_HUMAN (1-1503): 4.96e-67: 255: 22.48		ANK2_HUMAN (1-3898): 0: 1610: 80.85
+	Hs
		174745 SPTN2_HUMAN (1-1506): 1.07e-58: 228: 23.02		ANK2_HUMAN (1-3898): 0: 1610: 80.85
+	Hs
		1030639 SPTN1_HUMAN (2-1101): 1.58e-38: 161: 22.69		ANK2_HUMAN (1-3898): 0: 1610: 80.85
+	Hs
		1030712 MACF1_HUMAN (4-1586): 7.47e-24: 113: 13.88		ANK2_HUMAN (1-3898): 0: 1610: 80.85
+	Hs
		547433 DMD_HUMAN (952-2365): 2.82e-20: 101: 12.52		ANK2_HUMAN (1-3898): 0: 1610: 80.85
+	Hs
		592928 SPTB2_HUMAN (1-1503): 4.96e-67: 255: 22.48		ANK1_HUMAN (2-681): 0: 701: 34.64
+	Hs
		386434 SPTA1_HUMAN (1-2210): 2.76e-64: 246: 21.11		ANK1_HUMAN (2-681): 0: 701: 34.64
+	Hs
		1028748 SPTB2_HUMAN (1-1503): 4.96e-67: 255: 22.48		ANK3_HUMAN (2-714): 4.46e-164: 577: 34.31
+	Hs
		540235 SPTB1_HUMAN (1417-2410): 1.07e-23: 112: 16.09		ANK1_HUMAN (2-681): 0: 701: 34.64
+	Hs
		174752 SPTN2_HUMAN (1-1506): 1.07e-58: 228: 23.02		ANK3_HUMAN (2-714): 4.46e-164: 577: 34.31
+	Hs
		1091395 SPTN1_HUMAN (2-1101): 1.58e-38: 161: 22.69		ANK3_HUMAN (2-714): 4.46e-164: 577: 34.31
+	Hs
		1091457 SPTN4_HUMAN (1107-2378): 5.74e-31: 136: 15.80		ANK3_HUMAN (2-714): 4.46e-164: 577: 34.31
+	Hs
		1091401 PLEC_HUMAN (778-2427): 2.19e-23: 111: 9.37		ANK3_HUMAN (2-714): 4.46e-164: 577: 34.31
+	Mm
		109265 SPTB2_MOUSE (1-1503): 1.67e-66: 253: 22.48		ANK3_MOUSE (1069-1261): 1.56e-12: 76.5: 10.36
+	Mm
		1230054 CE290_MOUSE (156-2457): 1.25e-54: 214: 9.92		Q6KAP1_MOUSE (910-1357): 3.68e-13: 78.4: 10.06
+	Mm
		86327 B9EKJ1_MOUSE (2-1101): 1e-37: 159: 22.34		ANK3_MOUSE (1069-1261): 1.56e-12: 76.5: 10.36
+	Mm
		59636 Q6S385_MOUSE (843-2427): 3.93e-23: 110: 10.71		A2AM57_MOUSE (1-121): 1.28e-23: 112: 17.07
+	Mm
		59660 PLEC_MOUSE (843-2427): 4.07e-23: 110: 10.71		A2AM57_MOUSE (1-121): 1.28e-23: 112: 17.07
+	Rn
		267189 PLEC_RAT (2-1137): 1.19e-32: 142: 9.39		ANK3_RAT (1052-1261): 1.13e-09: 67.3: 9.52
+	Mm
		109260 Q3UGX2_MOUSE (1417-2410): 2.16e-22: 108: 15.90		ANK3_MOUSE (1069-1261): 1.56e-12: 76.5: 10.36