HitPredict

Interactor 1: NUMB (P16554)
Protein numb
Gene: NUMB

Interactor 2: AP2A (P91926)
AP-2 complex subunit alpha (Alpha-adaptin)
Gene: AP-2alpha

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	22474327, 12194853, 16139215, 18854163, 23523246, unassigned4
Identification Methods	affinity chromatography technology, pull down, experimental interaction detection
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008104 - intracellular protein localization GO:0045807 - positive regulation of endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 556 Dm			1 940
+	Hs
		323685 NUMB_HUMAN (42-546): 5.73e-93: 299: 36.92		AP2A2_HUMAN (1-940): 0: 825: 69.18
+	Hs
		344654 NUMB_HUMAN (42-546): 5.73e-93: 299: 36.92		AP2A1_HUMAN (1-940): 0: 810: 65.48
+	Rn
		1187300 Q3MUI1_RAT (42-465): 2.79e-76: 254: 41.20		Q66HM2_RAT (1-940): 0: 832: 69.46
+	Rn
		614863 Q3MUI1_RAT (42-465): 2.79e-76: 254: 41.20		AP2A2_RAT (1-940): 0: 831: 69.57
+	Mm
		604488 ANS1B_MOUSE (14-272): 2.85e-54: 200: 18.28		AP2A2_MOUSE (1-940): 0: 833: 69.67
+	Hs
		323702 DAB2_HUMAN (35-546): 5.66e-54: 197: 11.81		AP2A2_HUMAN (1-940): 0: 825: 69.18
+	Hs
		344671 DAB2_HUMAN (35-546): 5.66e-54: 197: 11.81		AP2A1_HUMAN (1-940): 0: 810: 65.48
+	Hs
		344670 SHC2_HUMAN (57-367): 5.36e-53: 191: 15.00		AP2A1_HUMAN (1-940): 0: 810: 65.48
+	Dm
		597776 NUMB_DROME (1-556): 2.6e-136: 408: 100.00		Q7KVR8_DROME (4-705): 0: 592: 25.31
+	Ce
		63399 A5JYR4_CAEEL (28-454): 4.94e-61: 211: 14.51		Q22601_CAEEL (1-940): 0: 770: 65.29
+	Hs
		889253 NUMB_HUMAN (42-546): 5.73e-93: 299: 36.92		AP2B1_HUMAN (33-935): 0: 654: 16.31
+	Hs
		889269 NUMB_HUMAN (42-546): 5.73e-93: 299: 36.92		AP1B1_HUMAN (33-935): 0: 636: 15.31
+	Rn
		986881 Q3MUI1_RAT (42-465): 2.79e-76: 254: 41.20		AP2B1_RAT (33-935): 0: 654: 16.31
+	Hs
		989183 NUMBL_HUMAN (30-552): 2.96e-73: 246: 36.45		AP2B1_HUMAN (33-935): 0: 654: 16.31
+	Hs
		989068 ANS1A_HUMAN (6-268): 1.48e-57: 209: 18.15		AP2B1_HUMAN (33-935): 0: 654: 16.31
+	Hs
		988991 ARH_HUMAN (43-324): 1e-58: 199: 18.24		AP2B1_HUMAN (33-935): 0: 654: 16.31
+	Hs
		988948 DAB2_HUMAN (35-546): 5.66e-54: 197: 11.81		AP2B1_HUMAN (33-935): 0: 654: 16.31
+	Hs
		1083250 ARH_HUMAN (43-324): 1e-58: 199: 18.24		AP1B1_HUMAN (33-935): 0: 636: 15.31
+	Hs
		1022105 SHC2_HUMAN (57-367): 5.36e-53: 191: 15.00		AP1B1_HUMAN (33-935): 0: 636: 15.31
+	Ce
		63402 A5JYR4_CAEEL (28-454): 4.94e-61: 211: 14.51		Q8WQB3_CAEEL (8-815): 0: 557: 24.73